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CYK18 Antibody (C-term)

Mouse Monoclonal Antibody (Mab)

     
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  • 1 - CYK18 Antibody (C-term) AW5679
    All lanes : Anti-CYK18 Antibody (C-term) at1:2000 dilution Lane 1: Hela whole cell lysate Lane 2: A431 whole cell lysate Lane 3: HepG2 whole cell lysate Lane 4: human liver lysate Lane 5: mouse lung lysate Lane 6: NIH/3T3 whole cell lysate Lane 7: Rat liver lysate Lane 8: C6 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-mouse IgG, (H+L),Peroxidase conjugated at 1/10000 dilution. Predicted band size : 48 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • 3 - CYK18 Antibody (C-term) AW5679
    Immunofluorescent analysis of 4% paraformaldehyde-fixed, 0. 1% Triton X-100 permeabilized HeLa (human cervical epithelial adenocarcinoma cell line) cells labeling Pdx1 with AW5679 at 1/25 dilution, followed by Dylight® 488-conjugated goat anti-mouse IgG (NA166821) secondary antibody at 1/200 dilution (green). Immunofluorescence image showing cytoskeleton staining on HeLa cell line. The nuclear counter stain is DAPI (blue).
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
IF, WB
Primary Accession P05783
Reactivity Human
Host Mouse
Clonality Monoclonal
Calculated MW H=48 KDa
Isotype IgG3
Antigen Source HUMAN
Additional Information
Gene ID 3875
Antigen Region 400-430
Other Names Keratin, type I cytoskeletal 18, Cell proliferation-inducing gene 46 protein, Cytokeratin-18, CK-18, Keratin-18, K18, KRT18, CYK18
Dilution WB~~1:2000
IF~~1:25
Target/Specificity This CYK18 Monoclonal antibody is generated from mouses immunized with a KLH conjugated synthetic peptide selected from the 400-430 region of human CYK18.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCYK18 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KRT18
Synonyms CYK18
Function Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.
Cellular Location Cytoplasm, perinuclear region. Nucleus, nucleolus
Tissue Location Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma.

BACKGROUND

Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.

REFERENCES

Oshima R.G., et al. Differentiation 33:61-68(1986).
Kim J.W., et al. Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
Kalnine N., et al. Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
Suzuki Y., et al. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Kulesh D.A., et al. Mol. Cell. Biol. 8:1540-1550(1988).

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