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ERLIN2 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
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  • 1 - ERLIN2 Antibody (C-term) AW5675
    All lanes : Anti-ERLIN2 Antibody (C-term) at 1:1000 dilution Lane 1: 293T/17 whole cell lysate Lane 2: A431 whole cell lysate Lane 3: human breast lysate Lane 4: C2C12 whole cell lysate Lane 5: human placenta lysate Lane 6: NIH/3T3 whole cell lysate Lane 7: mouse kidney lysate Lane 8: rat liver lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 38 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession O94905
Other Accession Q5R7C5
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Clone Names RB38591
Calculated MW H=38;M=38;R=38 KDa
Additional info
Gene ID 11160
Other Names Erlin-2, Endoplasmic reticulum lipid raft-associated protein 2, Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2, SPFH domain-containing protein 2, ERLIN2, C8orf2, SPFH2
Target/Specificity This ERLIN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 307-333 amino acids from the C-terminal region of human ERLIN2.
Dilution WB~~1:1000
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsERLIN2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ERLIN2
Synonyms C8orf2, SPFH2
Function Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Also involved in ITPR1 degradation by the ERAD pathway.
Cellular Location Endoplasmic reticulum membrane; Single-pass type II membrane protein. Note=Associated with lipid raft-like domains of the endoplasmic reticulum membrane
Tissue Location Ubiquitous..

BACKGROUND

Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Also involved in ITPR1 degradation by the ERAD pathway.

REFERENCES

Wang, Y., et al. Biochim. Biophys. Acta 1793(11):1710-1718(2009)
Pearce, M.M., et al. J. Biol. Chem. 284(16):10433-10445(2009)
Pearce, M.M., et al. J. Biol. Chem. 282(28):20104-20115(2007)
Browman, D.T., et al. J. Cell. Sci. 119 (PT 15), 3149-3160 (2006) :
Garcia, M.J., et al. Oncogene 24(33):5235-5245(2005)

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