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H3f3b Antibody (C-Term)

Purified Rabbit Polyclonal Antibody (Pab)

     
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  • 1 - H3f3b Antibody (C-Term) AW5634
    All lanes : Anti-H3f3b Antibody (C-Term) at 1:2000 dilution Lane 1: mouse lung lysate Lane 2: mouse cerebellum lysate Lane 3: mouse spleen lysate Lane 4: NIH/3T3 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 15 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession P84244
Other Accession Q16695, P68432, Q42681, P68431, P68433, Q6LBF0, Q6LED0, P59226, Q6LBE3, P84227, Q6LCK1, P84230, P84229, Q6LCW8, Q64400, Q4QRF4, P08903, Q71T45, Q71DI3, P84231, Q402E1, P69246, P68429, P84228, Q6LBE8, P84234, P68430, A2Y533, Q2RAD9, P68427, P69248, P84232, Q76MV0, P68428, P84233, Q28D37, Q10
Reactivity Mouse
Predicted Human, Mouse, Monkey, Dog, Sheep, Chicken
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Clone Names RB53621
Calculated MW M=15 KDa
Additional info
Gene ID 15078;15081
Other Names Histone H33, H3f3a, H33a
Target/Specificity This H3f3b antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 103-136 amino acids from mouse H3f3b.
Dilution WB~~1:2000
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsH3f3b Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name H3f3a
Synonyms H3.3a
Function Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Cellular Location Nucleus. Chromosome.

BACKGROUND

Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

REFERENCES

Hraba-Renevey S.,et al.Nucleic Acids Res. 17:2449-2461(1989).
Bramlage B.,et al.Differentiation 62:13-20(1997).
Lopez-Alanon D.M.,et al.DNA Cell Biol. 16:639-644(1997).
Carninci P.,et al.Science 309:1559-1563(2005).
Mancini P.,et al.J. Mol. Evol. 59:458-463(2004).

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