注册 | 登录
所有产品
  • 所有产品
  • 一抗
  • 裂解液
>   首页   >   产品   >   一抗   >   SAMHD1 Antibody (Center)   

SAMHD1 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
标注"皇冠"的产品,是满足高质量标准的产品。
了解更多...
  • 1 - SAMHD1 Antibody (Center) AW5632
    All lanes : Anti-SAMHD1 Antibody (Center) at 1:2000 dilution Lane 1: THP-1 whole cell lysate Lane 2: Ramos whole cell lysate Lane 3: HepG2 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 72 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • 产品详情
  • 实验流程
  • 背景知识
Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession Q9Y3Z3
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Clone Names RB37219
Calculated MW H=72,69,64,68 KDa
Additional info
Gene ID 25939
Other Names Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, dNTPase, 315-, Dendritic cell-derived IFNG-induced protein, DCIP, Monocyte protein 5, MOP-5, SAM domain and HD domain-containing protein 1, SAMHD1, MOP5
Target/Specificity This SAMHD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 204-230 amino acids from the Central region of human SAMHD1.
Dilution WB~~0.25
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSAMHD1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SAMHD1
Synonyms MOP5
Function Host restriction nuclease that blocks early-stage virus replication in dendritic and other myeloid cells. Likewise, suppresses LINE-1 retrotransposon activity. May function by reducing the cellular dNTP levels to levels too low for retroviral reverse transcription to occur. May play a role in mediating proinflammatory responses to TNF-alpha signaling.
Cellular Location Nucleus
Tissue Location Expressed in heart, skeletal muscle, spleen, liver, small intestine, placenta, lung and peripheral blood leukocytes. No expression is seen in brain and thymus

BACKGROUND

This gene may play a role in regulation of the innate immune response. The encoded protein is upregulated in response to viral infection and may be involved in mediation of tumor necrosis factor-alpha proinflammatory responses. Mutations in this gene have been associated with Aicardi-Goutieres syndrome. [provided by RefSeq].

REFERENCES

Tomkova, H., et al. Eur J Dermatol 20(3):411-413(2010)
Dale, R.C., et al. Am. J. Med. Genet. A 152A (4), 938-942 (2010) :
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Rice, G.I., et al. Nat. Genet. 41(7):829-832(2009)
Liao, W., et al. Proteomics 8(13):2640-2650(2008)

FeedBack

终于等到您。感谢您使用ABGENT(百奇生物)抗体产品。
点击下方“我要评价 ”按钮提交您的反馈信息,您的反馈和评价是我们最宝贵的财富之一,
我们将在1-3个工作日内处理您的反馈信息。

如有疑问,联系:0512-69552906 tech.abgent@wuxiapptec.com.


我要评价