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HNRNPA1L2 Antibody (N-Term)

Purified Rabbit Polyclonal Antibody (Pab)

     
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  • 1 - HNRNPA1L2 Antibody (N-Term) AW5617
    All lanes : Anti-HNRNPA1L2 Antibody (N-Term) at 1:4000 dilution Lane 1: Hela whole cell lysate Lane 2: HepG2 whole cell lysate Lane 3: Jurkat whole cell lysate Lane 4: K562 whole cell lysate Lane 5: MCF-7 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 34 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • 2 - HNRNPA1L2 Antibody (N-Term) AW5617
    AW5615 staining HNRNPA1L2 in human breast carcinoma tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with formaldehyde and blocked with 3% BSA for 0. 5 hour at room temperature; antigen retrieval was by heat mediation with a citrate buffer (pH6). Samples were incubated with primary antibody (1/25) for 1 hours at 37°C. A undiluted biotinylated goat polyvalent antibody was used as the secondary antibody.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
IHC, WB
Primary Accession Q32P51
Other Accession P09867, P09651, Q28521, P49312, A5A6H4, P04256
Reactivity Human
Predicted Human, Monkey, Dog, Chicken
Host Rabbit
Clonality Polyclonal
Calculated MW H=34,29;M=29 KDa
Isotype Rabbit Ig
Antigen Source HUMAN
Additional Information
Antigen Region 22-56
Other Names Heterogeneous nuclear ribonucleoprotein A1-like 2, hnRNP A1-like 2, hnRNP core protein A1-like 2, HNRNPA1L2, HNRNPA1L
Dilution WB~~1:4000
IHC~~1:25
Target/Specificity This HNRNPA1L2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 22-56 amino acids from human HNRNPA1L2.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHNRNPA1L2 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HNRNPA1L2
Synonyms HNRNPA1L
Function Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection.
Cellular Location Nucleus. Cytoplasm EMBL; AK123159; -; NOT_ANNOTATED_CDS; mRNA EMBL; AL137058; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; CH471124; EAW52041.1; -; Genomic_DNA EMBL; BC108266; AAI08267.1; -; mRNA CCDS; CCDS31980.1; - RefSeq; NP_001011724.1; NM_001011724.1 RefSeq; NP_001011725.1; NM_001011725.1 UniGene; Hs.447506; - ProteinModelPortal; Q32P51; - SMR; Q32P51; - BioGrid; 126887; 37 IntAct; Q32P51; 52 MINT; Q32P51; - STRING; 9606.ENSP00000341285; - iPTMnet; Q32P51; - PhosphoSitePlus; Q32P51; - SwissPalm; Q32P51; - BioMuta; HNRNPA1L2; - DMDM; 190356061; - EPD; Q32P51; - jPOST; Q32P51; - MaxQB; Q32P51; - PaxDb; Q32P51; - PeptideAtlas; Q32P51; - PRIDE; Q32P51; - ProteomicsDB; 61627; - Ensembl; ENST00000357495; ENSP00000350090; ENSG00000139675 GeneID; 144983; - KEGG; hsa:144983; - UCSC; uc021rjy.3; human CTD; 144983; - EuPathDB; HostDB:ENSG00000139675.11; - GeneCards; HNRNPA1L2; - HGNC; HGNC:27067; HNRNPA1L2 neXtProt; NX_Q32P51; - PharmGKB; PA164720701; - eggNOG; KOG0118; Eukaryota eggNOG; COG0724; LUCA GeneTree; ENSGT00940000153200; - HOGENOM; HOG000234442; - InParanoid; Q32P51; - KO; K12741; - OMA; KGHNCEV; - OrthoDB; 1202220at2759; - PhylomeDB; Q32P51; - TreeFam; TF351342; - ChiTaRS; HNRNPA1L2; human GenomeRNAi; 144983; - PRO; PR:Q32P51; - Proteomes; UP000005640; Chromosome 13 Bgee; ENSG00000139675; Expressed in 148 organ(s), highest expression level in small intestine Peyer's patch ExpressionAtlas; Q32P51; baseline and differential Genevisible; Q32P51; HS GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell GO; GO:1990904; C:ribonucleoprotein complex; IBA:GO_Central GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW GO; GO:0003729; F:mRNA binding; IBA:GO_Central GO; GO:0003723; F:RNA binding; IBA:GO_Central GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW CDD; cd12580; RRM2_hnRNPA1; 1 Gene3D; 3.30.70.330; -; 2 InterPro; IPR021662; HnRNPA1 InterPro; IPR034803; hnRNPA1_RRM2 InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf InterPro; IPR035979; RBD_domain_sf InterPro; IPR000504; RRM_dom Pfam; PF11627; HnRNPA1; 1 Pfam; PF00076; RRM_1; 2 SMART; SM00360; RRM; 2 SUPFAM; SSF54928; SSF54928; 2 PROSITE; PS50102; RRM; 2 2: Evidence at transcript level; Acetylation; Complete proteome; Cytoplasm; Methylation; mRNA processing; mRNA splicing; mRNA transport; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Ribonucleoprotein; RNA-binding; Spliceosome; Transport CHAIN 1 320 Heterogeneous nuclear ribonucleoprotein A1-like 2 /FTId=PRO_0000318848 DOMAIN 14 97 RRM 1. {ECO:0000255|PROSITE- ProRule:PRU00176} DOMAIN 105 184 RRM 2. {ECO:0000255|PROSITE- ProRule:PRU00176} REGION 4 94 Globular A domain REGION 95 185 Globular B domain REGION 218 240 RNA-binding RGG-box REGION 268 305 Nuclear targeting sequence COMPBIAS 195 317 Gly-rich MOD_RES 6 6 Phosphoserine {ECO:0000250|UniProtKB:P49312} MOD_RES 22 22 Phosphoserine {ECO:0000250|UniProtKB:P49312} MOD_RES 194 194 Asymmetric dimethylarginine; alternate {ECO:0000250|UniProtKB:P09867} MOD_RES 194 194 Omega-N-methylarginine; alternate {ECO:0000250|UniProtKB:P49312} MOD_RES 206 206 Asymmetric dimethylarginine; alternate {ECO:0000250|UniProtKB:P49312} MOD_RES 206 206 Omega-N-methylarginine; alternate {ECO:0000250|UniProtKB:P49312} MOD_RES 218 218 Asymmetric dimethylarginine; alternate {ECO:0000250|UniProtKB:P49312} MOD_RES 218 218 Omega-N-methylarginine; alternate {ECO:0000250|UniProtKB:P49312} MOD_RES 225 225 Asymmetric dimethylarginine; alternate {ECO:0000250|UniProtKB:P49312} MOD_RES 225 225 Omega-N-methylarginine; alternate {ECO:0000250|UniProtKB:P49312} MOD_RES 284 284 Omega-N-methylarginine {ECO:0000250|UniProtKB:P49312} MOD_RES 298 298 N6-acetyllysine {ECO:0000250|UniProtKB:P49312} VARIANT 215 215 N -> D (in dbSNP:rs9536212) /FTId=VAR_038904 CONFLICT 289 289 Y -> C (in Ref. 4; AAI08267) SEQUENCE 320 AA; 34225 MW; 002EE1547DAC04A2 CRC64; MSKSASPKEP EQLRKLFIGG LSFETTDESL RSHFEQWGTL TDCVVMRDPN TKRSRGFGFV TYATVEEVDA AMNTTPHKVD GRVVEPKRAV SREDSQRPGA HLTVKKIFVG GIKEDTEEHH LRDYFEQYGK IEVIEIMTDR GSGKKRGFAF VTFDDHDSVD KIVIQKYHTV KGHNCEVRKA LPKQEMASAS SSQRGRRGSG NFGGGRGDGF GGNDNFGRGG NFSGRGGFGG SCGGGGYGGS GDGYNGFGND GSNFGGGGSY NDFGNYNNQS SNFGPMKGGN FGGRSSGPYG GGGQYFAKPQ NQGGYGVSSS SSSYGSGRRF

BACKGROUND

Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection.

REFERENCES

Ota T.,et al.Nat. Genet. 36:40-45(2004).
Dunham A.,et al.Nature 428:522-528(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.

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