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Mlkl Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
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  • 1 - Mlkl Antibody (C-term) AW5609
    All lanes : Anti-Mlkl Antibody (C-term) at 1:2000 dilution Lane 1: mouse liver lysate Lane 2: mouse lung lysate Lane 3: mouse testis lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 54 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession Q9D2Y4
Reactivity Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW M=54,53 KDa
Isotype Rabbit Ig
Antigen Source HUMAN
Additional Information
Gene ID 74568
Antigen Region 444-472
Other Names Mixed lineage kinase domain-like protein, Mlkl {ECO:0000312|EMBL:AAH237551, ECO:0000312|MGI:MGI:1921818}
Dilution WB~~0.25
Target/Specificity This Mouse Mlkl antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 444-472 amino acids from the C-terminal region of mouse Mlkl.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMlkl Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Mlkl {ECO:0000312|EMBL:AAH23755.1, ECO:0000312|MGI:MGI:1921818}
Function Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity.
Cellular Location Cytoplasm. Cell membrane. Note=Localizes to the cytoplasm and translocates to the plasma membrane on necroptosis induction.
Tissue Location Highly expressed in thymus, colon, intestine, liver, spleen and lung. Expressed at much lower level in skeletal muscle, heart and kidney. Not detected in brain

BACKGROUND

The protein kinase domain is predicted to be catalytically inactive. Molecular function: protein binding. There are two isoforms.

REFERENCES

Bisson, N., et al. Cell Cycle 7(7):909-916(2008)

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