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>   首页   >   产品   >   一抗   >   MEN1 Antibody (N-term)   

MEN1 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
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  • 1 - MEN1 Antibody (N-term) AW5602
    All lanes : Anti-MEN1 Antibody (N-term) at 1:2000 dilution Lane 1: CEM whole cell lysate Lane 2: Jurkat whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 68 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • 3 - MEN1 Antibody (N-term) AW5602
    Confocal immunofluorescent analysis of MEN1 Antibody (N-term)(Cat#AW5602) with Hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green).DAPI was used to stain the cell nuclear (blue).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
IF
Primary Accession O00255
Other Accession Q0P5I0, A2SXS5, O88559, Q9WVR8
Reactivity Human
Predicted Human, Dog, Chicken
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Clone Names RB33738
Calculated MW H=68,67,64;R=67,61;M=68,61 KDa
Additional info
Gene ID 4221
Other Names Menin, MEN1, SCG2
Target/Specificity This MEN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 3-32 amino acids from the N-terminal region of human MEN1.
Dilution WB~~1:2000
IF~~1:10~50
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMEN1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MEN1
Synonyms SCG2
Function Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression (By similarity). May be involved in DNA repair.
Cellular Location Nucleus. Note=Concentrated in nuclear body-like structures. Relocates to the nuclear matrix upon gamma irradiation
Tissue Location Ubiquitous.

BACKGROUND

This gene encodes menin, a putative tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. In vitro studies have shown menin is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcriptional activation by JunD, however, the function of this protein is not known. Two messages have been detected on northern blots but the larger message has not been characterized. Alternative splicing results in multiple transcript variants.

REFERENCES

Stratakis, C., et al. Clin. Genet. 78(5):457-463(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)
Skandarajah, A., et al. World J Surg 34(6):1294-1298(2010)
Calender, A. Bull. Acad. Natl. Med. 194(1):81-95(2010)

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