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MMP25 Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
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  • 1 - MMP25 Antibody (C-term) AW5583
    All lanes : Anti-MMP25 Antibody (R485) at 1:1000 dilution Lane 1: HT-29 whole cell lysate Lane 2: HL-60 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 63 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession Q9NPA2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW H=63 KDa
Isotype Rabbit Ig
Antigen Source HUMAN
Additional Information
Gene ID 64386
Antigen Region 470-499
Other Names Matrix metalloproteinase-25, MMP-25, 3424-, Leukolysin, Membrane-type matrix metalloproteinase 6, MT-MMP 6, MTMMP6, Membrane-type-6 matrix metalloproteinase, MT6-MMP, MT6MMP, MMP25, MMP20, MMPL1, MT6MMP
Dilution WB~~1:1000
Target/Specificity This MMP25 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 470-499 amino acids from the C-terminal region of human MMP25.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMMP25 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MMP25
Synonyms MMP20, MMPL1, MT6MMP
Function May activate progelatinase A.
Cellular Location Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Secreted, extracellular space, extracellular matrix
Tissue Location Expressed predominantly in leukocytes, lung and spleen. Expressed also in colon carcinoma, astrocytoma and glioblastomas
Research Areas

BACKGROUND

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, MMP25 is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. In addition, it is thought that this protein is activated intracellularly by furin-like enzymes. This protein activates MMP2 by cleavage. The gene has previously been referred to as MMP20 but has been renamed matrix metalloproteinase 25 (MMP25).

REFERENCES

Matsuda, A., et al., J. Biol. Chem. 278(38):36350-36357 (2003).
Velasco, G., et al., Cancer Res. 60(4):877-882 (2000).
Nagase, H., et al., J. Biol. Chem. 274(31):21491-21494 (1999).
Pei, D., Cell Res. 9(4):291-303 (1999).
Kojima, S., et al., FEBS Lett. 480 (2-3), 142-146 (2000).

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