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STX4 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
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  • 1 - STX4 Antibody (Center) AW5579
    All lanes : Anti-STX4 Antibody (Center) at 1:1000 dilution Lane 1: HL-60 whole cell lysate Lane 2: MDA-MB-231 whole cell lysate Lane 3: A431 whole cell lysate Lane 4: PC-12 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 34 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession Q12846
Other Accession Q3SWZ3, P70452, Q08850
Reactivity Human, Rat
Predicted Human, Dog, Chicken
Host Rabbit
Clonality Polyclonal
Calculated MW H=34;M=34;R=34 KDa
Isotype Rabbit Ig
Antigen Source HUMAN
Additional Information
Gene ID 6810
Antigen Region 132-160
Other Names Syntaxin-4, Renal carcinoma antigen NY-REN-31, STX4, STX4A
Dilution WB~~1:1000
Target/Specificity This STX4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 132-160 amino acids from the Central region of human STX4.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSTX4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name STX4
Synonyms STX4A
Function Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones.
Cellular Location Cell membrane; Single-pass type IV membrane protein
Tissue Location Expressed in neutrophils and neutrophil- differentiated HL-60 cells. Expression in neutrophils increases with differentiation.
Research Areas

BACKGROUND

Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones.

REFERENCES

Evesson, F.J., et al. J. Biol. Chem. 285(37):28529-28539(2010)
Kennedy, M.J., et al. Cell 141(3):524-535(2010)
Brochetta, C., et al. Biochim. Biophys. Acta 1783(10):1781-1791(2008)
Cooper, G.M., et al. Blood 112(4):1022-1027(2008)
Low, S.H., et al. Mol. Biol. Cell 17(2):977-989(2006)

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