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KCNMB2 Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
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  • 1 - KCNMB2 Antibody (N-term) AW5564
    All lanes : Anti-KCNMB2 Antibody (N-term) at 1:2000 dilution Lane 1: human brain lysate Lane 2: human heart lysate Lane 3: human kidney lysate Lane 4: HepG2 whole cell lysate Lane 5: mouse brain lysate Lane 6: rat brain lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 27 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession Q9Y691
Other Accession Q9CZM9, Q811Q0
Reactivity Human, Mouse, Rat
Predicted Dog, Chicken
Host Rabbit
Clonality Polyclonal
Calculated MW H=27;M=27;R=27 KDa
Isotype Rabbit Ig
Antigen Source HUMAN
Additional Information
Gene ID 10242
Antigen Region 32-66
Other Names Calcium-activated potassium channel subunit beta-2, BK channel subunit beta-2, BKbeta2, Hbeta2, Calcium-activated potassium channel, subfamily M subunit beta-2, Charybdotoxin receptor subunit beta-2, Hbeta3, K(VCA)beta-2, Maxi K channel subunit beta-2, Slo-beta-2, KCNMB2
Dilution WB~~1:2000
Target/Specificity This KCNMB2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 32-66 amino acids from the N-terminal region of human KCNMB2.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsKCNMB2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KCNMB2
Function Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex. May participate in KCNMA1 inactivation in chromaffin cells of the adrenal gland or in hippocampal CA1 neurons.
Cellular Location Membrane; Multi-pass membrane protein.
Tissue Location Expressed in kidney, heart and brain. Highly expressed in ovary. Expressed at low level in other tissues
Research Areas

BACKGROUND

Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex. May participate in KCNMA1 inactivation in chromaffin cells of the adrenal gland or in hippocampal CA1 neurons.

REFERENCES

Wallner M.,et al.Proc. Natl. Acad. Sci. U.S.A. 96:4137-4142(1999).
Brenner R.,et al.J. Biol. Chem. 275:6453-6461(2000).
Xia X.-M.,et al.J. Neurosci. 19:5255-5264(1999).
Meera P.,et al.Proc. Natl. Acad. Sci. U.S.A. 97:5562-5567(2000).
Xia X.-M.,et al.J. Gen. Physiol. 121:125-148(2003).

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