|Calculated MW||H=21 KDa|
|Other Names||Phosphatidylethanolamine-binding protein 1, PEBP-1, HCNPpp, Neuropolypeptide h3, Prostatic-binding protein, Raf kinase inhibitor protein, RKIP, Hippocampal cholinergic neurostimulating peptide, HCNP, PEBP1, PBP, PEBP|
|Target/Specificity||This PBP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 132-168 amino acids from the Central region of human PBP.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PBP Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation.|
PBP binds ATP, opioids and phosphatidylethanolamine, exhibiting a lower affinity for phosphatidylinositol and phosphatidylcholine. This serine protease inhibitor inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase. PBP contains hippocampal cholinergic neurostimulating peptide (HCNP), which may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase.
Tohdoh, N., et al., Brain Res. Mol. Brain Res. 30(2):381-384 (1995). Hori, N., et al., Gene 140(2):293-294 (1994). Seddiqi, N., et al., J. Mol. Evol. 39(6):655-660 (1994). Moore, C., et al., Brain Res. Mol. Brain Res. 37 (1-2), 74-78 (1996).