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VPS37C Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
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  • 1 - VPS37C Antibody (Center) AW5543
    All lanes : Anti-VPS37C Antibody (Center) at 1:1000 dilution Lane 1: Raji whole cell lysate Lane 2: Hela whole cell lysate Lane 3: HT-29 whole cell lysate Lane 4: PC-12 whole cell lysate Lane 5: PC-3 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 39 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession A5D8V6
Reactivity Human, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW H=39 KDa
Isotype Rabbit Ig
Antigen Source HUMAN
Additional Information
Gene ID 55048
Antigen Region 142-169
Other Names Vacuolar protein sorting-associated protein 37C, hVps37C, ESCRT-I complex subunit VPS37C, VPS37C, PML39
Dilution WB~~1:1000
Target/Specificity This VPS37C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 142-169 amino acids from the Central region of human VPS37C.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsVPS37C Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name VPS37C
Synonyms PML39
Function Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
Cellular Location Late endosome membrane; Peripheral membrane protein. Note=Probably associates with membranes. Recruited to the plasma membrane by HIV-1
Research Areas

BACKGROUND

VPS37C is a subunit of ESCRT-I (endosomal sorting complex required for transport I), a complex in the class E vacuolar protein sorting (VPS) pathway required for sorting ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies (Eastman et al., 2005 [PubMed 15509564]).

REFERENCES

Rose, J. Phd, et al. Mol. Med. (2010) In press :
Hosgood, H.D. III, et al. Occup Environ Med 66(12):848-853(2009)
Eastman, S.W., et al. J. Biol. Chem. 280(1):628-636(2005)

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