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SNRPC Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
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  • 1 - SNRPC Antibody (C-term) AW5526
    All lanes : Anti-SNRPC Antibody (C-term) at 1:1000 dilution Lane 1: K562 whole cell lysate Lane 2: Hela whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 17 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • 14 - SNRPC Antibody (C-term) AW5526
    Formalin-fixed and paraffin-embedded human brain tissue reacted with SNRPC Antibody (C-term) (Cat.#AW5526), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • 4 - SNRPC Antibody (C-term) AW5526
    SNRPC Antibody (C-term) (Cat. #AW5526) flow cytometry analysis of K562 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
FC, IHC-P, WB
Primary Accession P09234
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW H=17;M=17;R=17 KDa
Isotype Rabbit Ig
Antigen Source HUMAN
Additional Information
Gene ID 6631
Antigen Region 148-179
Other Names U1 small nuclear ribonucleoprotein C {ECO:0000255|HAMAP-Rule:MF_03153}, U1 snRNP C {ECO:0000255|HAMAP-Rule:MF_03153}, U1-C {ECO:0000255|HAMAP-Rule:MF_03153}, U1C {ECO:0000255|HAMAP-Rule:MF_03153}, SNRPC {ECO:0000255|HAMAP-Rule:MF_03153}
Dilution WB~~1:1000
IHC-P~~1:50~100
FC~~1:10~50
Target/Specificity This SNRPC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 148-179 amino acids from the C-terminal region of human SNRPC.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSNRPC Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SNRPC {ECO:0000255|HAMAP-Rule:MF_03153}
Function Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
Cellular Location Nucleus.

BACKGROUND

SNRPC is associated with snRNP U1.

REFERENCES

Hochleitner,E.O., J. Biol. Chem. 280 (4), 2536-2542 (2005)
Muto,Y., J. Mol. Biol. 341 (1), 185-198 (2004)
Forch,P., EMBO J. 21 (24), 6882-6892 (2002)
Gunnewiek,J.M., Nucleic Acids Res. 23 (23), 4864-4871 (1995)

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