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MBL2 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
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  • 1 - MBL2 Antibody (C-term) AW5525
    All lanes : Anti-MBL2 Antibody (C-term) at 1:1000 dilution Lane 1: HepG2 whole cell lysate Lane 2: A549 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 26 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • 3 - MBL2 Antibody (C-term) AW5525
    Confocal immunofluorescent analysis of MBL2 Antibody (C-term)(Cat#AW5525) with A549 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
  • 14 - MBL2 Antibody (C-term) AW5525
    MBL2 Antibody (C-term) (Cat. #AW5525)immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of MBL2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
IHC-P, IF, WB
Primary Accession P11226
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW H=26 KDa
Isotype Rabbit Ig
Antigen Source HUMAN
Additional Information
Gene ID 4153
Antigen Region 188-222
Other Names Mannose-binding protein C, MBP-C, Collectin-1, MBP1, Mannan-binding protein, Mannose-binding lectin, MBL2, COLEC1, MBL
Dilution WB~~1:1000
IF~~1:10~50
IHC-P~~1:10~50
Target/Specificity This MBL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 188-222 amino acids from the C-terminal region of human MBL2.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMBL2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MBL2
Synonyms COLEC1, MBL
Function Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA.
Cellular Location Secreted.
Tissue Location Plasma protein produced mainly in the liver.
Research Areas

BACKGROUND

This gene encodes the soluble mannose-binding lectin or mannose-binding protein found in serum. The protein encoded belongs to the collectin family and is an important element in the innate immune system. The protein recognizes mannose and N-acetylglucosamine on many microorganisms, and is capable of activating the classical complement pathway. Deficiencies of this gene have been associated with susceptibility to autoimmune and infectious diseases.

REFERENCES

Auriti, C., et al. Hum. Immunol. 71(11):1084-1088(2010)
Fraser, D.A., et al. J. Immunol. 185(7):3932-3939(2010)
de Wit, E., et al. Mamm. Genome (2010) In press :
Filho, R.M., et al. Viral Immunol. 23(4):449-453(2010)
Hu, Y., et al. Viral Immunol. 23(4):443-447(2010)

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