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CRABP2 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
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  • 1 - CRABP2 Antibody (C-term) AW5524
    All lanes : Anti-CRABP2 Antibody (C-term) at 1:1000 dilution Lane 1: MCF-7 whole cell lysate Lane 2: MDA-MB-453 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 16 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession P29373
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW H=16;M=16;R=16 KDa
Isotype Rabbit Ig
Antigen Source HUMAN
Additional Information
Gene ID 1382
Antigen Region 102-136
Other Names Cellular retinoic acid-binding protein 2, Cellular retinoic acid-binding protein II, CRABP-II, CRABP2
Dilution WB~~1:1000
Target/Specificity This CRABP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 102-136 amino acids from the C-terminal region of human CRABP2.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCRABP2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CRABP2
Function Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors.
Cellular Location Cytoplasm. Endoplasmic reticulum. Nucleus. Note=Upon ligand binding, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus
Research Areas

BACKGROUND

A number of specific carrier proteins for members of the vitamin A family have been discovered. Cellular retinoic acid binding proteins (CRABP) are low molecular weight proteins whose precise function remains unknown. The inducibility of the CRABP2 gene suggests that this isoform is important in retinoic acid-mediated regulation of human skin growth and differentiation. It has been postulated that the CRABP2 gene is transcriptionally regulated by a newly synthesized regulatory protein. [provided by RefSeq].

REFERENCES

Sola, R., et al. Atherosclerosis 211(2):630-637(2010) Manolescu, D.C., et al. Pediatr. Res. 67(6):598-602(2010) Calmon, M.F., et al. Neoplasia 11(12):1329-1339(2009) Corlazzoli, F., et al. PLoS ONE 4 (1), E4305 (2009) : Gupta, A., et al. Exp. Cell Res. 314(20):3663-3668(2008)

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