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CD74 Antibody

Purified Mouse Monoclonal Antibody (Mab)

     
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  • 1 - CD74 Antibody AW5503
    All lanes : Anti-CD74 Antibody at 1:1000 dilution Lane 1: Daudi whole cell lysates Lane 2: Raji whole cell lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Mouse IgG, (H+L),Peroxidase conjugated at 1/10000 dilution Predicted band size : 34 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • 4 - CD74 Antibody AW5503
    Flow cytometric analysis of Raji cells using CD74(green, Cat#AW5503) compared to an isotype control of mouse IgG2b(blue). AW5503 was diluted at 1:25 dilution. An Alexa Fluor® 488 goat anti-mouse lgG at 1:400 dilution was used as the secondary antibody.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
FC, WB
Primary Accession P04233
Reactivity Human
Host Mouse
Clonality Monoclonal
Calculated MW H=34,26,18 KDa
Isotype IgG2b,κ
Antigen Source HUMAN
Additional Information
Gene ID 972
Antigen Region 1-232
Other Names HLA class II histocompatibility antigen gamma chain, HLA-DR antigens-associated invariant chain, Ia antigen-associated invariant chain, Ii, p33, CD74, CD74, DHLAG
Dilution WB~~1:1000
FC~~1:25
Target/Specificity This antibody is generated from a mouse immunized with a recombinant protein.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCD74 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CD74
Synonyms DHLAG
Function Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.
Cellular Location Cell membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane. Golgi apparatus, trans-Golgi network. Endosome Lysosome. Note=Transits through a number of intracellular compartments in the endocytic pathway. It can either undergo proteolysis or reach the cell membrane
Research Areas

BACKGROUND

Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.

REFERENCES

Claesson L.,et al.Proc. Natl. Acad. Sci. U.S.A. 80:7395-7399(1983).
Strubin M.,et al.EMBO J. 3:869-872(1984).
Kudo J.,et al.Nucleic Acids Res. 13:8827-8841(1985).
O'Sullivan D.M.,et al.Proc. Natl. Acad. Sci. U.S.A. 83:4484-4488(1986).
Kalnine N.,et al.Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.

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