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MMP14 Antibody (C-term)

Mouse Monoclonal Antibody (Mab)

     
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  • 1 - MMP14 Antibody (C-term) AW5500
    All lanes : Anti-MMP14 Antibody (C-term) at 1:1000 dilution Lane 1: A2058 whole cell lysates Lane 2: HT-1080 whole cell lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 66 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession P50281
Reactivity Human
Host Mouse
Clonality Monoclonal
Calculated MW H=66 KDa
Isotype IgM
Antigen Source HUMAN
Additional Information
Gene ID 4323
Antigen Region 485-519
Other Names Matrix metalloproteinase-14, MMP-14, MMP-X1, Membrane-type matrix metalloproteinase 1, MT-MMP 1, MTMMP1, Membrane-type-1 matrix metalloproteinase, MT1-MMP, MT1MMP, MMP14
Dilution WB~~1:1000
Target/Specificity This MMP14 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 470-519 amino acids from the C-terminal region of human MMP14.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMMP14 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MMP14
Function Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro- MMP2.
Cellular Location Membrane; Single-pass type I membrane protein. Melanosome. Cytoplasm Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Forms a complex with BST2 and localizes to the cytoplasm
Tissue Location Expressed in stromal cells of colon, breast, and head and neck. Expressed in lung tumors
Research Areas

BACKGROUND

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion.

REFERENCES

Onimaru, M., et al. Arterioscler. Thromb. Vasc. Biol. 30(4):818-826(2010)
Wipff, J., et al. J. Rheumatol. 37(3):599-602(2010)
Liao, M.C., et al. Biochemistry 49(6):1127-1136(2010)

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