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(Mouse) Suz12 Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

     
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  • 1 - (Mouse) Suz12 Antibody (Center) AW5499
    All lanes : Anti-Suz12 Antibody (Center) at 1:1000 dilution Lane 1: F9 whole cell lysates Lane 2: SW480 whole cell lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 83 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession Q80U70
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW M=83;H=83 KDa
Isotype Rabbit Ig
Antigen Source HUMAN
Additional Information
Gene ID 52615
Antigen Region 496-530
Other Names Polycomb protein Suz12, Suppressor of zeste 12 protein homolog, Suz12, D11Ertd530e, Kiaa0160
Dilution WB~~1:1000
Target/Specificity This Mouse Suz12 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 496-530 amino acids from the Central region of Mouse Suz12.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Precautions(Mouse) Suz12 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Suz12
Synonyms D11Ertd530e, Kiaa0160
Function Polycomb group (PcG) protein. Component of the PRC2/EED- EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (By similarity). Genes repressed by the PRC2/EED-EZH2 complex include HOXA7, HOXB6 and HOXC8.
Cellular Location Nucleus. Chromosome. Note=Localizes to the inactive X chromosome in trophoblast stem cells

BACKGROUND

Polycomb group (PcG) protein. Component of the PRC2/EED- EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (By similarity). Genes repressed by the PRC2/EED-EZH2 complex include HOXA7, HOXB6 and HOXC8.

REFERENCES

Okazaki N.,et al.DNA Res. 10:35-48(2003).
Church D.M.,et al.PLoS Biol. 7:E1000112-E1000112(2009).
Pasini D.,et al.EMBO J. 23:4061-4071(2004).
Umlauf D.,et al.Nat. Genet. 36:1296-1300(2004).
Kuzmichev A.,et al.Proc. Natl. Acad. Sci. U.S.A. 102:1859-1864(2005).

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