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Mouse Pax6 Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
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  • 1 - Mouse Pax6 Antibody (C-term) AW5488
    All lanes : Anti-Pax6 Antibody (C-term) at 1:1000 dilution Lane 1: mouse cerebellum lysates Lane 2: rat cerebellum lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 47 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession P63015
Reactivity Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW M=47;H=47;R=47 KDa
Isotype Rabbit Ig
Antigen Source HUMAN
Additional Information
Gene ID 18508
Antigen Region 404-436
Other Names Paired box protein Pax-6, Oculorhombin, Pax6, Pax-6, Sey
Dilution WB~~1:1000
Target/Specificity This Mouse Pax6 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 404-436 amino acids from the C-terminal region of Mouse Pax6.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Pax6 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Pax6
Synonyms Pax-6, Sey
Function Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells. Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity).
Cellular Location Nucleus.
Tissue Location Isoform 1 and isoform 3 are the major isoforms among different eye tissues. Isoform 1 and isoform 3 are expressed in the retina and cornea. In the lens epithelium, isoform 1 is relatively abundant, but isoform 3 is barely detectable
Research Areas

BACKGROUND

Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells. Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity).

REFERENCES

Walther C.,et al.Development 113:1435-1449(1991).
Favor J.,et al.Genetics 159:1689-1700(2001).
Carninci P.,et al.Science 309:1559-1563(2005).
Walther C.,et al.Genomics 11:424-434(1991).
Ton C.C.T.,et al.Genomics 13:251-256(1992).

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