癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
(Mouse) Dpf2 Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | Q61103 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | M=44;H=44,24 KDa |
| Isotype | Rabbit Ig |
| Antigen Source | HUMAN |
| Gene ID | 19708 |
|---|---|
| Antigen Region | 125-159 |
| Other Names | Zinc finger protein ubi-d4, Apoptosis response zinc finger protein, BRG1-associated factor 45D, BAF45D, D4, zinc and double PHD fingers family 2, Protein requiem, Dpf2, Baf45d, Req, Ubid4 |
| Dilution | WB~~1:1000 |
| Target/Specificity | This mouse Dpf2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 125-159 amino acids from the Central region of mouse Dpf2. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | (Mouse) Dpf2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Dpf2 |
|---|---|
| Synonyms | Baf45d, Req, Ubid4 |
| Function | Plays an active role in transcriptional regulation by binding modified histones H3 and H4. Is a negative regulator of myeloid differentiation of hematopoietic progenitor cells (By similarity). Might also have a role in the development and maturation of lymphoid cells (PubMed:7961935). Involved in the regulation of non-canonical NF-kappa-B pathway (By similarity). |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q92785}. Cytoplasm {ECO:0000250|UniProtKB:Q92785} |
| Tissue Location | In embryo, highest levels are seen in brain, eyes, thymus and olfactory epithelium in nose, whereas several other tissues, including the musculoskeletal system, show moderate expression. In adult, higher expression in testis, medium in thymus and spleen, lower in certain parts of the brain as the hippocampus. No expression in adult heart, lung, liver, duodenum and kidney. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
May be a transcription factor required for the apoptosis response following survival factor withdrawal from myeloid cells. Might also have a role in the development and maturation of lymphoid cells.
REFERENCES
Mertsalov I.B.,et al.Mamm. Genome 11:72-74(2000).
Carninci P.,et al.Science 309:1559-1563(2005).
Gabig T.G.,et al.J. Biol. Chem. 269:29515-29519(1994).
Gabig T.G.,et al.Mamm. Genome 9:660-665(1998).
Lessard J.,et al.Neuron 55:201-215(2007).
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