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CDA Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

     
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  • 1 - CDA Antibody (Center) AW5473
    All lanes : Anti-CDA Antibody (Center) at 1:1000 dilution Lane 1: human liver lysates Lane 2: Hela whole cell lysates Lane 3: mouse kidney lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/10000 dilution Predicted band size : 16 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession P32320
Reactivity Human, Mouse
Predicted Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Clone Names RB17605
Calculated MW H=16;M=16;R=16 KDa
Additional info
Gene ID 978
Other Names Cytidine deaminase, Cytidine aminohydrolase, CDA, CDD
Target/Specificity This CDA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 51-83 amino acids from the Central region of human CDA.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCDA Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CDA
Synonyms CDD
Function This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
Tissue Location Highly expressed in granulocytes while expression is very low in fibroblasts, chondrocytes, monocytes, and T- as well as B-cell lines

BACKGROUND

CDA forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. This protein is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in the CDA gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias.

REFERENCES

Laliberte J., Momparler R.L.Cancer Res. 54:5401-5407(1994)
Demontis S., Terao M.Biochim. Biophys. Acta 1443:323-333(1998)
Kuhn K., Bertling W.M., Emmrich F.Biochem. Biophys. Res. Commun. 190:1-7(1993)

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