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Mouse Ddr2 Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

     
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  • 1 - Mouse Ddr2 Antibody (Center) AW5414
    All lanes : Anti-Ddr2 Antibody (Center) at 1:1000 dilution Lane 1: mouse lung lysates Lane 2: NIH/3T3 whole cell lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/10000 dilution Predicted band size : 96 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession Q62371
Reactivity Mouse
Predicted Human
Host Rabbit
Clonality Polyclonal
Calculated MW M=96;H=97 KDa
Isotype Rabbit Ig
Antigen Source HUMAN
Additional Information
Gene ID 18214
Antigen Region 503-537
Other Names Discoidin domain-containing receptor 2, Discoidin domain receptor 2, CD167 antigen-like family member B, Neurotrophic tyrosine kinase, receptor-related 3, Receptor protein-tyrosine kinase TKT, Tyrosine-protein kinase TYRO10, CD167b, Ddr2, Ntrkr3, Tkt, Tyro10
Dilution WB~~1:1000
Target/Specificity This Mouse Ddr2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 503-537 amino acids from the Central region of Mouse Ddr2.
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Ddr2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Ddr2
Synonyms Ntrkr3, Tkt, Tyro10
Function Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.
Cellular Location Cell membrane; Single-pass type I membrane protein
Tissue Location Widely expressed. Detected in lung, ovary, skin and in testis Leydig cells (at protein level). Widely expressed. Detected at high levels in heart, lung, skeletal muscle, central nervous system (CNS) and kidney, and at lower levels in brain and testis. Detected in chondrocytes in tibia growth plates of young mice.
Research Areas

BACKGROUND

Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.

REFERENCES

Karn T.,et al.Oncogene 8:3433-3440(1993).
Lai C.,et al.Oncogene 9:877-883(1994).
Labrador J.P.,et al.EMBO Rep. 2:446-452(2001).
Olaso E.,et al.J. Biol. Chem. 277:3606-3613(2002).
Ikeda K.,et al.J. Biol. Chem. 277:19206-19212(2002).

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