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MYBPC3 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
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  • 1 - MYBPC3 Antibody (N-term) AW5399
    All lanes : Anti-MYBPC3 Antibody (N-term) at 1:1000 dilution Lane 1: mouse heart lysates Lane 2: rat heart lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/10000 dilution Predicted band size : 141 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession Q14896
Other Accession P56741, O70468, NP_000247.2
Reactivity Mouse, Rat
Predicted Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Clone Names RB31023
Calculated MW H=141;M=141;R=141 KDa
Additional info
Gene ID 4607
Other Names Myosin-binding protein C, cardiac-type, Cardiac MyBP-C, C-protein, cardiac muscle isoform, MYBPC3
Target/Specificity This MYBPC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 189-218 amino acids from the N-terminal region of human MYBPC3.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMYBPC3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MYBPC3
Function Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role.
Research Areas

BACKGROUND

MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin-binding protein C is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. MYBPC3, the cardiac isoform, is expressed exclussively in heart muscle. Regulatory phosphorylation of the cardiac isoform in vivo by cAMP-dependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction. Mutations in MYBPC3 are one cause of familial hypertrophic cardiomyopathy.

REFERENCES

Millat, G., et al. Clin. Chim. Acta 411 (23-24), 1983-1991 (2010) :
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Millat, G., et al. Eur J Med Genet 53(5):261-267(2010)
Zimmerman, R.S., et al. Genet. Med. 12(5):268-278(2010)
Brion, M., et al. Ann. Clin. Lab. Sci. 40(3):285-289(2010)

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