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Ntrk3 Antibody

Purified Mouse Monoclonal Antibody (Mab)

     
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  • 1 - Ntrk3 Antibody AW5393
    All lanes : Anti-Ntrk3 Antibody at 1:1000 dilution Lane 1: human brain lysates Lane 2: mouse brain lysates Lane 3: rat brain lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Mouse IgG, (H+L),Peroxidase conjugated at 1/10000 dilution Predicted band size : 93 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession Q6VNS1
Reactivity Human, Mouse, Rat
Host Mouse
Clonality Monoclonal
Calculated MW H=93,56,68;M=93,56,68 KDa
Isotype IgG1,k
Antigen Source HUMAN
Additional Information
Gene ID 18213
Other Names NT-3 growth factor receptor, GP145-TrkC, Trk-C, Neurotrophic tyrosine kinase receptor type 3, TrkC tyrosine kinase, Ntrk3, TrkC
Dilution WB~~1:1000
Target/Specificity This Ntrk3 antibody is generated from a mouse immunized with a recombinant protein of human Ntrk3.
Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsNtrk3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Ntrk3
Synonyms TrkC
Function Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Isoform 2 expression is restricted to specific areas in adult brain. Isoform 3 transcripts are readily detected early during embryogenesis and are expressed predominantly in adult brain and gonads.
Research Areas

BACKGROUND

Receptor for neurotrophin-3 (NT-3). This is a tyrosine- protein kinase receptor. Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1 (By similarity).

REFERENCES

Yamauchi J.,et al.Proc. Natl. Acad. Sci. U.S.A. 100:14421-14426(2003).
Menn B.,et al.J. Comp. Neurol. 401:47-64(1998).
Ballif B.A.,et al.J. Proteome Res. 7:311-318(2008).

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