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CHML Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
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  • 1 - CHML Antibody (C-term) AW5373
    All lanes : Anti-CHML Antibody (C-term) at 1/1000 dilution Lane 1: HT-1080 whole cell lysates Lane 2: Hela whole cell lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/10000 dilution Predicted band size : 74 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • 4 - CHML Antibody (C-term) AW5373
    Flow cytometric analysis of Hela cells using CHML Antibody (C-term)(green, Cat#AW5373) compared to an isotype control of rabbit IgG(blue). AW5373 was diluted at 1:25 dilution. An Alexa Fluor® 488 goat anti-rabbit lgG at 1:400 dilution was used as the secondary antibody.
  • 14 - CHML Antibody (C-term) AW5373
    Immunohistochemical analysis of paraffin-embedded H. stomach section using CHML Antibody (C-term)(Cat#AW5373). AW5373 was diluted at 1:100 dilution. A peroxidase-conjugated goat anti-rabbit IgG at 1:400 dilution was used as the secondary antibody, followed by DAB staining.
  • 14 - CHML Antibody (C-term) AW5373
    Immunohistochemical analysis of paraffin-embedded R. cerebellum section using CHML Antibody (C-term)(Cat#AW5373). AW5373 was diluted at 1:100 dilution. A peroxidase-conjugated goat anti-rabbit IgG at 1:400 dilution was used as the secondary antibody, followed by DAB staining.
  • 14 - CHML Antibody (C-term) AW5373
    Immunohistochemical analysis of paraffin-embedded M. cerebellum section using CHML Antibody (C-term)(Cat#AW5373). AW5373 was diluted at 1:100 dilution. A peroxidase-conjugated goat anti-rabbit IgG at 1:400 dilution was used as the secondary antibody, followed by DAB staining.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
IHC-P, FC, WB
Primary Accession P26374
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW H=74 KDa
Isotype Rabbit Ig
Antigen Source HUMAN
Additional Information
Gene ID 1122
Antigen Region 624-656
Other Names Rab proteins geranylgeranyltransferase component A 2, Choroideremia-like protein, Rab escort protein 2, REP-2, CHML, REP2
Dilution WB~~1:1000
FC~~1:25
IHC-P~~1:25
Target/Specificity This CHML antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 624-656 amino acids from the C-terminal region of human CHML.
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCHML Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CHML
Synonyms REP2
Function Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Less effective than CHM in supporting prenylation of Rab3 family.
Cellular Location Cytoplasm, cytosol
Research Areas

BACKGROUND

Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Less effective than CHM in supporting prenylation of Rab3 family.

REFERENCES

Cremers F.P.M.,et al.Hum. Mol. Genet. 1:71-75(1992).
Kasper G.,et al.Gene 295:27-32(2002).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.

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