|Calculated MW||H=32,13 KDa|
|Other Names||Erythrocyte band 7 integral membrane protein, Protein 72b, Stomatin, STOM, BND7, EPB72|
|Target/Specificity||This STOM antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 2-36 amino acids from the N-terminal region of human STOM.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||STOM Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulates ion channel activity and transmembrane ion transport. Regulates ASIC2 and ASIC3 channel activity.|
|Cellular Location||Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Lipid-anchor; Cytoplasmic side Melanosome. Cytoplasmic vesicle. Note=Exposed on the cytoplasmic surface of the membrane. Associated with lipid rafts Concentrates preferentially in plasma membrane protrusions and in a juxta-nuclear region which may represent Golgi-derived vesicles Colocalizes with actin. Identified by mass spectrometry in melanosome fractions from stage I to stage IV|
|Tissue Location||Detected in erythrocytes (at protein level). Widely expressed.|
Thought to regulate cation conductance. May regulate ASIC2 and ASIC3 gating (By similarity).
Hiebl-Dirschmied C.M.,et al.Biochim. Biophys. Acta 1090:123-124(1991).
Stewart G.W.,et al.Blood 79:1593-1601(1992).
Unfried I.,et al.Genomics 30:521-528(1995).
Gallagher P.G.,et al.J. Biol. Chem. 270:26358-26363(1995).
Halleck A.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.