|Calculated MW||H=45,44,43,42;M=45,43,42,26;Rat=45,43 KDa|
|Other Names||Plasminogen activator inhibitor 1 RNA-binding protein, PAI1 RNA-binding protein 1, PAI-RBP1, SERPINE1 mRNA-binding protein 1, SERBP1, PAIRBP1|
|Target/Specificity||This SERBP1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 149-183 amino acids from the Central region of human SERBP1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SERBP1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in the regulation of mRNA stability. Binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay.|
|Cellular Location||Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Note=Also found in perinuclear regions|
|Tissue Location||Expressed at high level in the heart, skeletal muscle and kidney, and at low levels in placenta, liver and brain|
May play a role in the regulation of mRNA stability. Binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay.
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Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Gregory S.G.,et al.Nature 441:315-321(2006).