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SERBP1 Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

     
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  • 1 - SERBP1 Antibody (Center) AW5368
    All lanes : Anti-SERBP1 Antibody (Center) at 1:1/1000 dilution Lane 1: A549 whole cell lysates Lane 2: Hela whole cell lysates Lane 3: HepG2 whole cell lysates Lane 4: MCF-7 whole cell lysates Lane 5: MDA-MB-468 whole cell lysates Lane 6: SK-BR-3 whole cell lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/10000 dilution Predicted band size : 45 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession Q8NC51
Reactivity Human
Predicted Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW H=45,44,43,42;M=45,43,42,26;Rat=45,43 KDa
Isotype Rabbit Ig
Antigen Source HUMAN
Additional Information
Antigen Region 149-183
Other Names Plasminogen activator inhibitor 1 RNA-binding protein, PAI1 RNA-binding protein 1, PAI-RBP1, SERPINE1 mRNA-binding protein 1, SERBP1, PAIRBP1
Dilution WB~~1:1000
Target/Specificity This SERBP1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 149-183 amino acids from the Central region of human SERBP1.
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSERBP1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SERBP1 (HGNC:17860)
Synonyms PAIRBP1
Function May play a role in the regulation of mRNA stability. Binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay. Seems to play a role in PML-nuclear bodies formation (PubMed:28695742).
Cellular Location Cytoplasm. Nucleus Cytoplasm, perinuclear region
Tissue Location Expressed at high level in the heart, skeletal muscle and kidney, and at low levels in placenta, liver and brain EMBL; AF151813; AAD34050.1; -; mRNA EMBL; AL080119; CAB45718.1; -; mRNA EMBL; AK074970; BAC11324.1; -; mRNA EMBL; CR457383; CAG33664.1; -; mRNA EMBL; AL590559; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; BC003049; AAH03049.1; -; mRNA EMBL; BC008045; AAH08045.1; -; mRNA EMBL; BC017449; AAH17449.1; -; mRNA EMBL; BC019273; AAH19273.1; -; mRNA EMBL; BC020555; AAH20555.1; -; mRNA EMBL; BC002488; AAH02488.1; -; mRNA EMBL; BC026916; AAH26916.1; -; mRNA EMBL; AY032853; AAK51130.1; -; mRNA CCDS; CCDS30746.1; -. [Q8NC51-1] CCDS; CCDS30747.1; -. [Q8NC51-3] CCDS; CCDS30748.1; -. [Q8NC51-2] CCDS; CCDS639.1; -. [Q8NC51-4] PIR; T12456; T12456 RefSeq; NP_001018077.1; NM_001018067.1. [Q8NC51-1] RefSeq; NP_001018078.1; NM_001018068.1. [Q8NC51-2] RefSeq; NP_001018079.1; NM_001018069.1. [Q8NC51-3] RefSeq; NP_056455.3; NM_015640.3. [Q8NC51-4] UniGene; Hs.530412; - PDB; 4V6X; EM; 5.00 A; Ah=1-408 PDBsum; 4V6X; - ProteinModelPortal; Q8NC51; - BioGrid; 117571; 135 DIP; DIP-33819N; - IntAct; Q8NC51; 63 MINT; Q8NC51; - STRING; 9606.ENSP00000360034; - CarbonylDB; Q8NC51; - iPTMnet; Q8NC51; - PhosphoSitePlus; Q8NC51; - SwissPalm; Q8NC51; - BioMuta; SERBP1; - DMDM; 52783206; - EPD; Q8NC51; - jPOST; Q8NC51; - MaxQB; Q8NC51; - PaxDb; Q8NC51; - PeptideAtlas; Q8NC51; - PRIDE; Q8NC51; - ProteomicsDB; 72850; - ProteomicsDB; 72851; -. [Q8NC51-2] ProteomicsDB; 72852; -. [Q8NC51-3] ProteomicsDB; 72853; -. [Q8NC51-4] TopDownProteomics; Q8NC51-1; -. [Q8NC51-1] TopDownProteomics; Q8NC51-2; -. [Q8NC51-2] TopDownProteomics; Q8NC51-3; -. [Q8NC51-3] TopDownProteomics; Q8NC51-4; -. [Q8NC51-4] DNASU; 26135; - Ensembl; ENST00000361219; ENSP00000354591; ENSG00000142864. [Q8NC51-3] Ensembl; ENST00000370990; ENSP00000360029; ENSG00000142864. [Q8NC51-2] Ensembl; ENST00000370994; ENSP00000360033; ENSG00000142864. [Q8NC51-4] Ensembl; ENST00000370995; ENSP00000360034; ENSG00000142864. [Q8NC51-1] GeneID; 26135; - KEGG; hsa:26135; - UCSC; uc001ddv.4; human. [Q8NC51-1] CTD; 26135; - DisGeNET; 26135; - EuPathDB; HostDB:ENSG00000142864.14; - GeneCards; SERBP1; - HGNC; HGNC:17860; SERBP1 HPA; CAB026297; - HPA; HPA020559; - MIM; 607378; gene neXtProt; NX_Q8NC51; - OpenTargets; ENSG00000142864; - PharmGKB; PA413; - eggNOG; KOG2945; Eukaryota eggNOG; ENOG410YBHR; LUCA GeneTree; ENSGT00520000055591; - HOVERGEN; HBG056357; - InParanoid; Q8NC51; - KO; K13199; - OMA; QNRKREF; - OrthoDB; 1183388at2759; - PhylomeDB; Q8NC51; - TreeFam; TF318374; - ChiTaRS; SERBP1; human GeneWiki; SERBP1; - GenomeRNAi; 26135; - PRO; PR:Q8NC51; - Proteomes; UP000005640; Chromosome 1 Bgee; ENSG00000142864; Expressed in 236 organ(s), highest expression level in testis ExpressionAtlas; Q8NC51; baseline and differential Genevisible; Q8NC51; HS GO; GO:0005737; C:cytoplasm; IDA:UniProtKB GO; GO:0005829; C:cytosol; IDA:HPA GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB GO; GO:0016020; C:membrane; HDA:UniProtKB GO; GO:0005634; C:nucleus; IDA:UniProtKB GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell GO; GO:0005886; C:plasma membrane; IEA:Ensembl GO; GO:0045296; F:cadherin binding; HDA:BHF-UCL GO; GO:0003730; F:mRNA 3'-UTR binding; IDA:HGNC GO; GO:0003723; F:RNA binding; HDA:UniProtKB GO; GO:0032183; F:SUMO binding; IDA:UniProtKB GO; GO:0030578; P:PML body organization; IDA:UniProtKB GO; GO:0042981; P:regulation of apoptotic process; IEA:Ensembl GO; GO:0043488; P:regulation of mRNA stability; NAS:HGNC InterPro; IPR039764; HABP4/SERBP1 InterPro; IPR006861; HABP4_PAIRBP1-bd InterPro; IPR032381; IHABP4_N InterPro; IPR027205; SERBP1 PANTHER; PTHR12299; PTHR12299; 1 PANTHER; PTHR12299:SF29; PTHR12299:SF29; 1 Pfam; PF04774; HABP4_PAI-RBP1; 1 Pfam; PF16174; IHABP4_N; 1 SMART; SM01233; HABP4_PAI-RBP1; 1 1: Evidence at protein level; 3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Isopeptide bond; Methylation; Nucleus; Phosphoprotein; Reference proteome; RNA-binding; Ubl conjugation INIT_MET 1 1 Removed. {ECO:0000244|PubMed:25944712, ECO:0000269|Ref.8} CHAIN 2 408 Plasminogen activator inhibitor 1 RNA- binding protein /FTId=PRO_0000058182 MOD_RES 25 25 Phosphoserine MOD_RES 52 52 N6-acetyllysine; alternate {ECO:0000250|UniProtKB:Q9CY58} MOD_RES 68 68 N6-acetyllysine MOD_RES 122 122 N6-acetyllysine MOD_RES 140 140 N6-acetyllysine MOD_RES 165 165 Omega-N-methylarginine {ECO:0000250|UniProtKB:Q9CY58} MOD_RES 188 188 Omega-N-methylarginine {ECO:0000250|UniProtKB:Q9CY58} MOD_RES 197 197 Phosphoserine {ECO:0000250|UniProtKB:Q6AXS5} MOD_RES 203 203 Phosphoserine MOD_RES 205 205 Phosphoserine MOD_RES 208 208 Phosphoserine MOD_RES 211 211 N6-acetyllysine; alternate MOD_RES 216 216 Omega-N-methylarginine MOD_RES 221 221 Phosphoserine MOD_RES 234 234 Phosphoserine MOD_RES 329 329 N6-acetyllysine {ECO:0000250|UniProtKB:Q9CY58} MOD_RES 330 330 Phosphoserine MOD_RES 364 364 Omega-N-methylarginine MOD_RES 367 367 Omega-N-methylarginine MOD_RES 370 370 Omega-N-methylarginine MOD_RES 392 392 Phosphoserine MOD_RES 394 394 Phosphoserine CROSSLNK 52 52 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternate. CROSSLNK 102 102 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternate. CROSSLNK 102 102 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate. CROSSLNK 211 211 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate. CROSSLNK 228 228 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternate. CROSSLNK 228 228 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate. CROSSLNK 281 281 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternate. CROSSLNK 281 281 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate. VAR_SEQ 203 208 Missing (in isoform 2 and isoform 4) {ECO:0000303|PubMed:11230166, ECO:0000303|PubMed:15489334, ECO:0000303|Ref.4} /FTId=VSP_011630 VAR_SEQ 233 247 Missing (in isoform 3 and isoform 4) {ECO:0000303|PubMed:10810093, ECO:0000303|PubMed:11230166, ECO:0000303|PubMed:15489334, ECO:0000303|Ref.4, ECO:0000303|Ref.9} /FTId=VSP_011631 MUTAGEN 102 102 K->R: Not sumoylated; when associated with R-228 and R-281 MUTAGEN 228 228 K->R: Not sumoylated; when associated with R-102 and R-281 MUTAGEN 281 281 K->R: Not sumoylated; when associated with R-102 and R-228 CONFLICT 55 55 A -> T (in Ref. 1; AAD34050) CONFLICT 101 101 L -> F (in Ref. 1; AAD34050) CONFLICT 312 312 N -> S (in Ref. 3; BAC11324) CONFLICT 376 376 R -> C (in Ref. 6; AAH02488) SEQUENCE 408 AA; 44965 MW; 2289992374FA6A96 CRC64; MPGHLQEGFG CVVTNRFDQL FDDESDPFEV LKAAENKKKE AGGGGVGGPG AKSAAQAAAQ TNSNAAGKQL RKESQKDRKN PLPPSVGVVD KKEETQPPVA LKKEGIRRVG RRPDQQLQGE GKIIDRRPER RPPRERRFEK PLEEKGEGGE FSVDRPIIDR PIRGRGGLGR GRGGRGRGMG RGDGFDSRGK REFDRHSGSD RSSFSHYSGL KHEDKRGGSG SHNWGTVKDE LTESPKYIQK QISYNYSDLD QSNVTEETPE GEEHHPVADT ENKENEVEEV KEEGPKEMTL DEWKAIQNKD RAKVEFNIRK PNEGADGQWK KGFVLHKSKS EEAHAEDSVM DHHFRKPAND ITSQLEINFG DLGRPGRGGR GGRGGRGRGG RPNRGSRTDK SSASAPDVDD PEAFPALA
Research Areas

BACKGROUND

May play a role in the regulation of mRNA stability. Binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay.

REFERENCES

Lai C.-H.,et al.Genome Res. 10:703-713(2000).
Wiemann S.,et al.Genome Res. 11:422-435(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Gregory S.G.,et al.Nature 441:315-321(2006).

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