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CTSD(heavy chain) Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

     
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  • 1 - CTSD(heavy chain) Antibody (Center) AW5367
    All lanes : Anti-CTSD(heavy chain) Antibody (Center) at 1/1000 dilution Lane 1: A431 whole cell lysates Lane 2: MCF-7 whole cell lysates Lane 3: SK-BR-3 whole cell lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/10000 dilution Predicted band size : 45 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession P07339
Other Accession P18242, P80209
Reactivity Human
Predicted Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW H=45;M=45;Rat=45 KDa
Isotype Rabbit Ig
Antigen Source HUMAN
Additional Information
Gene ID 1509
Antigen Region 241-273
Other Names Cathepsin D, Cathepsin D light chain, Cathepsin D heavy chain, CTSD, CPSD
Dilution WB~~1:1000
Target/Specificity This CTSD(heavy chain) antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 241-273 amino acids from the Central region of human CTSD(heavy chain).
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCTSD(heavy chain) Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CTSD
Synonyms CPSD
Function Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.
Cellular Location Lysosome. Melanosome. Secreted, extracellular space. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. In aortic samples, detected as an extracellular protein loosely bound to the matrix (PubMed:20551380).
Tissue Location Expressed in the aorta extrcellular space (at protein level).
Research Areas

BACKGROUND

Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.

REFERENCES

Faust P.L.,et al.Proc. Natl. Acad. Sci. U.S.A. 82:4910-4914(1985).
Westley B.R.,et al.Nucleic Acids Res. 15:3773-3786(1987).
Redecker B.,et al.DNA Cell Biol. 10:423-431(1991).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Kalnine N.,et al.Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.

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