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Maspin Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
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  • 1 - Maspin Antibody (Center) AW5365
    All lanes : Anti-Maspin Antibody (Center)(AW5365) at 1/1000 dilution Lane 1: Hela whole cell lysates Lane 2: HT-29 whole cell lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/10000 dilution Predicted band size : 42 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • 14 - Maspin Antibody (Center) AW5365
    Maspin Antibody (Center) (Cat. #AW5365)immunohistochemistry analysis in formalin fixed and paraffin embedded human breast tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of Maspin Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
  • 3 - Maspin Antibody (Center) AW5365
    Confocal immunofluorescent analysis of Maspin Antibody (Center)(Cat#AW5365) with A2058 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
IF, IHC-P, WB
Primary Accession P36952
Other Accession P70124, NP_002630.2
Reactivity Human
Predicted Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW H=42,26;M=42;Rat=42 KDa
Isotype Rabbit Ig
Antigen Source HUMAN
Additional Information
Gene ID 5268
Antigen Region 94-123
Other Names SERPINB5; PI5; Serpin B5; Maspin; Peptidase inhibitor 5
Dilution WB~~1:1000
IHC-P~~1:50~100
IF~~1:10~50
Target/Specificity This Maspin antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 94-123 amino acids from the Central region of human Maspin.
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMaspin Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SERPINB5
Synonyms PI5
Function Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
Cellular Location Secreted, extracellular space.
Tissue Location Normal mammary epithelial cells.
Research Areas

BACKGROUND

SERPINB5 is a tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.

REFERENCES

Kim, J., et al. Tumour Biol. 31(5):471-476(2010)
Juengel, E., et al. World J Urol 28(4):465-471(2010)
Besgen, P., et al. J. Immunol. 184(9):5392-5402(2010)
Fung, C.L., et al. Histopathology 56(3):319-330(2010)
Adim, S.B., et al. World J Surg Oncol 8, 22 (2010) :

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