|Calculated MW||H=134;M=133 KDa|
|Other Names||Non-receptor tyrosine-protein kinase TYK2, TYK2|
|Target/Specificity||This TYK2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 887-922 amino acids from the C-terminal region of human TYK2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TYK2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.|
|Tissue Location||Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines|
Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.
Firmbach-Kraft I.,et al.Oncogene 5:1329-1336(1990).
Velazquez L.,et al.Cell 70:313-322(1992).
Krolewski J.J.,et al.Oncogene 5:277-282(1990).
Partanen J.,et al.Proc. Natl. Acad. Sci. U.S.A. 87:8913-8917(1990).
Colamonici O.,et al.Mol. Cell. Biol. 14:8133-8142(1994).