|Calculated MW||H=71,62 KDa|
|Other Names||ATAD3A;ATPase family AAA domain-containing protein 3A|
|Target/Specificity||This ATAD3A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24-48 amino acids from the N-terminal region of human ATAD3A.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ATAD3A Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Essential for mitochondrial network organization, mitochondrial metabolism and cell growth at organism and cellular level. May play an important in mitochondrial protein synthesis. May also participate in mitochondrial DNA replication. May bind to mitochondrial DNA D-loops and contribute to nucleoid stability. Required for enhanced channeling of cholesterol for hormone- dependent steroidogenesis.|
|Cellular Location||Mitochondrion inner membrane; Single-pass membrane protein. Mitochondrion matrix, mitochondrion nucleoid Note=In the mitochondrial inner membrane, enriched in sites with the potential to form contacts with the outer membrane. The N- terminal domain interacts with the inner surface of the mitochondrial outer membrane and the C-terminal domain localizes in a specific matrix compartment, where it is associated with nucleoids|
|Tissue Location||Overexpressed in lung adenocarcinomas (at protein level).|
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Gregory S.G., et al. Nature 441:315-321(2006).
Bienvenut W.V., et al. Submitted (JUL-2007) to UniProtKB.
Daub H., et al. Mol. Cell 31:438-448(2008).
Choudhary C., et al. Science 325:834-840(2009).