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GATA6 Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
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  • 1 - GATA6 Antibody (C-term) AW5321
    Western blot analysis of lysates from Hela,MCF-7 cell line (from left to right), using GATA6 Antibody (C-term)(Cat. #AW5321). AW5321 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody.Lysates at 20ug per lane.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession Q92908
Reactivity Human
Predicted Mouse, Rat
Host Rabbit
Clonality polyclonal
Calculated MW H=60, 45;M=59, 45;Rat=59 KDa
Isotype Rabbit Ig
Antigen Source HUMAN
Additional Information
Gene ID 2627
Antigen Region 551-585
Other Names Transcription factor GATA-6, GATA-binding factor 6, GATA6
Dilution WB~~1:1000
Target/Specificity This GATA6 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 551-585 amino acids from the C-terminal region of human GATA6.
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGATA6 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GATA6
Function Transcriptional activator (PubMed:19666519, PubMed:27756709, PubMed:22750565, PubMed:22824924). Regulates SEMA3C and PLXNA2 (PubMed:19666519). Involved in gene regulation specifically in the gastric epithelium (PubMed:9315713). May regulate genes that protect epithelial cells from bacterial infection (PubMed:16968778). Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (By similarity). Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity).
Cellular Location Nucleus
Tissue Location Expressed in heart, gut and gut-derived tissues
Research Areas

BACKGROUND

Transcriptional activator that regulates SEMA3C and PLXNA2. Thought to be important for regulating terminal differentiation and/or proliferation.

REFERENCES

Suzuki E.,et al.Genomics 38:283-290(1996).
Huggon I.C.,et al.Biochim. Biophys. Acta 1353:98-102(1997).
Yoshida T.,et al.FEBS Lett. 414:333-337(1997).
Nusbaum C.,et al.Nature 437:551-555(2005).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.

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