|Reactivity||Human, Mouse, Rat|
|Calculated MW||H=36;M=36;Rat=36 KDa|
|Other Names||4-dienoyl-CoA reductase, mitochondrial, 4-dienoyl-CoA reductase [NADPH], 4-enoyl-CoA reductase [NADPH], DECR1, DECR|
|Target/Specificity||This DECR1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 241-274 amino acids from the Central region of human DECR1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DECR1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3- enoyl-CoA.|
|Tissue Location||Heart = liver = pancreas > kidney >> skeletal muscle = lung.|
Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3- enoyl-CoA.
Koivuranta K.T.,et al.Biochem. J. 304:787-792(1994).
Ding J.H.,et al.Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases.
Helander H.M.,et al.Genomics 46:112-119(1997).
Nusbaum C.,et al.Nature 439:331-335(2006).
Choudhary C.,et al.Science 325:834-840(2009).