|Application ||IHC-P, IF, WB|
|Calculated MW||H=9;M=9 KDa|
|Other Names||NDUFA4;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4|
|Target/Specificity||This NDUA4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 56-80 amino acids from the C-terminal region of human NDUA4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NDUA4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cytochrome c oxidase (COX, complex IV) is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. Required for complex IV maintenance.|
|Cellular Location||Mitochondrion inner membrane; Peripheral membrane protein; Matrix side|
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Kim J.W., et al. Biochem. Mol. Biol. Int. 43:669-675(1997).
Kanagarajah D., et al. Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases.
Ebert L., et al. Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
Halleck A., et al. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Scherer S.W., et al. Science 300:767-772(2003).