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BCL2L11 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
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  • 1 - BCL2L11 Antibody (Center) AW5298
    Western blot analysis of lysates from K562,A431 cell line (from left to right), using BCL2L11 Antibody (Center)(Cat. #AW5298). AW5298 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody.
  • 14 - BCL2L11 Antibody (Center) AW5298
    Formalin-fixed and paraffin-embedded human colon carcinoma reacted with BCL2L11 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • 4 - BCL2L11 Antibody (Center) AW5298
    Flow cytometric analysis of WiDr cells using BCL2L11 Antibody (Center)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
  • 14 - BCL2L11 Antibody (Center) AW5298
    Immunohistochemical analysis of paraffin-embedded H. kidney section using BCL2L11 Antibody (Center)(Cat#AW5298). AW5298 was diluted at 1:25 dilution. A undiluted biotinylated goat polyvalent antibody was used as the secondary, followed by DAB staining.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
IHC-P, FC, WB
Primary Accession O43521
Other Accession O88498, O54918
Reactivity Human
Predicted Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW H=22,16,13,19,12,9,10,14,23;M=22,16,13;Rat=22,16,13,11 KDa
Isotype Rabbit Ig
Antigen Source HUMAN
Additional Information
Gene ID 10018
Antigen Region 134-160
Other Names BCL2L11; BIM; Bcl-2-like protein 11; Bcl2-interacting mediator of cell death
Dilution WB~~1:1000
IHC-P~~1:25
FC~~1:10~50
Target/Specificity This BCL2L11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 134-160 amino acids from the Central region of human BCL2L11.
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsBCL2L11 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BCL2L11
Synonyms BIM
Function Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis.
Cellular Location Endomembrane system; Peripheral membrane protein. Note=Associated with intracytoplasmic membranes. Isoform BimL: Mitochondrion. Isoform Bim-alpha1: Mitochondrion.
Tissue Location Isoform BimEL, isoform BimL and isoform BimS are the predominant isoforms and are ubiquitously expressed with a tissue-specific variation. Isoform Bim-gamma is most abundantly expressed in small intestine and colon, and in lower levels in spleen, prostate, testis, heart, liver and kidney
Research Areas

BACKGROUND

BCL2L11 belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator.

REFERENCES

Hippe,D.,et.al., J. Cell. Sci. 122 (PT 19), 3511-3521 (2009)
Putcha,G.V., et.al., Neuron 38 (6), 899-914 (2003)

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