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STAT5b Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
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  • 1 - STAT5b Antibody (C-term) AW5290
    Western blot analysis of lysates from HL-60,MCF-7 cell line,rat liver,rat spleen tissue (from left to right), using STAT5b Antibody (C-term)(Cat. #AW5290). AW5290 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession P51692
Other Accession P52632, Q9TUZ0, P42232, Q9TUM3
Reactivity Human, Rat
Predicted Mouse, Bovine
Host Rabbit
Clonality Polyclonal
Calculated MW H=90 M=90 Rat=90 KDa
Isotype Rabbit Ig
Antigen Source HUMAN
Additional Information
Gene ID 6777
Antigen Region 760-787
Other Names STAT5B; Signal transducer and activator of transcription 5B
Dilution WB~~1:1000
Target/Specificity This STAT5b antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 760-787 amino acids from the C-terminal region of human STAT5b.
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSTAT5b Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name STAT5B
Function Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription.
Cellular Location Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.
Research Areas

BACKGROUND

STAT5b is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.

REFERENCES

Xi, S., et al., Cancer Res. 63(20):6763-6771 (2003).
Uddin, S., et al., Biochem. Biophys. Res. Commun. 308(2):325-330 (2003).
Zhang, X., et al., J. Allergy Clin. Immunol. 112(1):93-101 (2003).
Yamashita, H., et al., Oncogene 22(11):1638-1652 (2003).
Kloth, M.T., et al., J. Biol. Chem. 278(3):1671-1679 (2003).

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