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CHRNA9 Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
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  • 1 - CHRNA9 Antibody (N-term) AW5287
    Western blot analysis of lysates from Raji,Ramos,Daudi cell line (from left to right), using CHRNA9 Antibody (N-term)(Cat. #AW5287). AW5287 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody.
  • 4 - CHRNA9 Antibody (N-term) AW5287
    Flow cytometric analysis of Jurkat cells using CHRNA9 Antibody (N-term)(green, Cat#AW5287) compared to an isotype control of rabbit IgG(blue). AW5287 was diluted at 1:25 dilution. An Alexa Fluor® 488 goat anti-rabbit lgG at 1:400 dilution was used as the secondary antibody.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
FC, WB
Primary Accession Q9UGM1
Reactivity Human
Predicted Rat
Host Rabbit
Clonality Polyclonal
Calculated MW H=55;Rat=55 KDa
Isotype Rabbit Ig
Antigen Source HUMAN
Additional Information
Gene ID 55584
Antigen Region 8-42
Other Names Neuronal acetylcholine receptor subunit alpha-9, Nicotinic acetylcholine receptor subunit alpha-9, NACHR alpha-9, CHRNA9, NACHRA9
Dilution WB~~1:1000
FC~~1:25
Target/Specificity This CHRNA9 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 8-42 amino acids from the N-terminal region of human CHRNA9.
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCHRNA9 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CHRNA9
Synonyms NACHRA9
Function Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding induces a conformation change that leads to the opening of an ion-conducting channel across the plasma membrane (PubMed:11752216, PubMed:25282151). The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane (PubMed:11752216, PubMed:25282151). In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. May also regulate keratinocyte adhesion (PubMed:11021840).
Cellular Location Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein Cell membrane; Multi-pass membrane protein
Tissue Location Expressed in cochlea, keratinocytes, pituitary gland, B-cells and T-cells.
Research Areas

BACKGROUND

Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. May also regulate keratinocyte adhesion.

REFERENCES

Sgard F.,et al.Mol. Pharmacol. 61:150-159(2002).
Lustig L.R.,et al.Cytogenet. Genome Res. 98:154-159(2002).
Hillier L.W.,et al.Nature 434:724-731(2005).
Nguyen V.T.,et al.Am. J. Pathol. 157:1377-1391(2000).
Peng H.,et al.Life Sci. 76:263-280(2004).

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