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FOXO3 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
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  • 1 - FOXO3 Antibody (N-term) AW5283
    Western blot analysis of lysates from Hela,Jurkat cell line (from left to right), using FOXO3 Antibody (N-term)(Cat. #AW5283). AW5283 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody.
  • 14 - FOXO3 Antibody (N-term) AW5283
    FOXO3 Antibody (N-term) (Cat. #AW5283)immunohistochemistry analysis in formalin fixed and paraffin embedded human breast carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of FOXO3 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
IHC-P, WB
Primary Accession O43524
Other Accession Q9WVH4, NP_963853.1, NP_001446.1
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW H=71 KDa
Isotype Rabbit Ig
Antigen Source HUMAN
Additional Information
Gene ID 2309
Antigen Region 1-30
Other Names FOXO3; FKHRL1; FOXO3A; Forkhead box protein O3; AF6q21 protein; Forkhead in rhabdomyosarcoma-like 1
Dilution WB~~1:1000
IHC-P~~1:10~50
Target/Specificity This FOXO3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human FOXO3.
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFOXO3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FOXO3
Synonyms FKHRL1, FOXO3A
Function Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post- transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation.
Cellular Location Cytoplasm, cytosol. Nucleus. Note=Translocates to the nucleus upon oxidative stress and in the absence of survival factors
Tissue Location Ubiquitous..
Research Areas

BACKGROUND

This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed.

REFERENCES

Zhuo de, X., et al. J. Biol. Chem. 285(41):31491-31501(2010)
Tudzarova, S., et al. EMBO J. 29(19):3381-3394(2010)
Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)
Mikse, O.R., et al. Cancer Res. 70(15):6205-6215(2010)
Chen, J., et al. PLoS ONE 5 (8), E12293 (2010) :

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