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ITA6 Antibody

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
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  • 1 - ITA6 Antibody AW5255
    Western blot analysis of lysates from A431 cell line and human placenta tissue (from left to right), using ITA6 Antibody(Cat. #AW5255). AW5255 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession P23229
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW H=127,122,119,124,10 KDa
Isotype Rabbit Ig
Antigen Source HUMAN
Additional Information
Gene ID 3655
Antigen Region 53-329
Other Names ITGA6; Integrin alpha-6; CD49 antigen-like family member F; VLA-6; CD_antigen=CD49f; Integrin alpha-6 heavy chain; Integrin alpha-6 light chain
Dilution WB~~ 1:1000
Target/Specificity This ITA6 antibody is generated from rabbits immunized with ITA6 recombinant protein.
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsITA6 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ITGA6
Function Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome.
Cellular Location Cell membrane; Single-pass type I membrane protein Cell membrane; Lipid-anchor
Tissue Location Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoforms containing segment X1 are ubiquitously expressed. Isoforms containing segment X1X2 are expressed in heart, kidney, placenta, colon, duodenum, myoblasts and myotubes, and in a limited number of cell lines; they are always coexpressed with the ubiquitous isoform containing segment X1. In some tissues (e.g. Salivary gland), isoforms containing cytoplasmic segment A and isoforms containing segment B are detected while in others, only isoforms containing one cytoplasmic segment are found (segment A in epidermis and segment B in kidney).
Research Areas

BACKGROUND

The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling.

REFERENCES

Kim, T.H., et al. Mol. Cancer Res. 7(10):1605-1612(2009)
Eeles, R.A., et al. Nat. Genet. 41(10):1116-1121(2009)
Boroujerdnia, M.G., et al. Pak. J. Biol. Sci. 12(4):360-366(2009)
Dai, J.Y., et al. BMC Cancer 9, 337 (2009)
Dydensborg, A.B., et al. BMC Cancer 9, 223 (2009)

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