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SOX8 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
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  • 1 - SOX8 Antibody (Center) AW5251
    Western blot analysis of lysates from SK-BR-3 cell line,human brain,human cerebellum tissue (from left to right), using SOX8 Antibody (Center)(Cat. #AW5251). AW5251 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession P57073
Other Accession NP_055402.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Clone Names RB36112
Calculated MW H=47 KDa
Additional info
Gene ID 30812
Other Names SOX8; Transcription factor SOX-8
Target/Specificity This SOX8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 225-253 amino acids from the Central region of human SOX8.
Dilution WB~~ 1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSOX8 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SOX8
Function May play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3' (By similarity).
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00267}
Research Areas

BACKGROUND

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein may be involved in brain development and function. Haploinsufficiency for this protein may contribute to the mental retardation found in haemoglobin H-related mental retardation (ART-16 syndrome).

REFERENCES

Nonaka, D. Am. J. Clin. Pathol. 131(5):731-736(2009)
Hoff, S., et al. J. Comp. Neurol. 509(4):356-371(2008)
Wissmuller, S., et al. Nucleic Acids Res. 34(6):1735-1744(2006)
Schepers, G., et al. J. Biol. Chem. 278(30):28101-28108(2003)
Gevaert, K., et al. Nat. Biotechnol. 21(5):566-569(2003)

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