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SFN Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
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  • 1 - SFN Antibody (Center) AW5213
    Western blot analysis of lysates from Hela cell line,mouse bladder tissue lysate,A431 cell line (from left to right), using SFN Antibody (Center)(Cat. #AW5213). AW5213 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession P31947
Other Accession O70456, Q0VC36, NP_006133.1
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW H=28,24;M=28 KDa
Isotype Rabbit Ig
Antigen Source HUMAN
Additional Information
Gene ID 2810
Antigen Region 120-149
Other Names SFN; HME1; 14-3-3 protein sigma; Epithelial cell marker protein 1; Stratifin
Dilution WB~~1:1000
Target/Specificity This SFN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 120-149 amino acids from the Central region of human SFN.
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSFN Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SFN
Synonyms HME1
Function Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53.
Cellular Location Cytoplasm. Nucleus. Secreted. Note=May be secreted by a non-classical secretory pathway
Tissue Location Present mainly in tissues enriched in stratified squamous keratinizing epithelium
Research Areas

BACKGROUND

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression.

REFERENCES

Ren, H.Z., et al. Dig. Dis. Sci. 55(9):2552-2560(2010)
Liu, Y., et al. Brain Res. 1336, 98-102 (2010) :
Pei, H.P., et al. Zhonghua Wei Chang Wai Ke Za Zhi 13(3):213-215(2010)
Syrjanen, S., et al. Am. J. Clin. Pathol. 133(2):232-240(2010)
Zurita, M., et al. BMC Cancer 10, 217 (2010) :

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