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BAIAP2 Antibody (C-term)

Mouse Monoclonal Antibody (Mab)

     
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  • 1 - BAIAP2 Antibody (C-term) AW5188
    Western blot analysis of lysates from K562 cell line,mouse brain tissue,U-251 MG cell line (from left to right), using BAIAP2 Antibody (C-term)(Cat. #AW5188). AW5188 was diluted at 1:1000 at each lane. A goat anti-mouse IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody.Lysates at 20ug per lane.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession Q9UQB8
Reactivity Human, Mouse
Host Mouse
Clonality Monoclonal
Calculated MW H=61 KDa
Isotype IgG2b
Antigen Source Human
Additional Information
Gene ID 10458
Antigen Region 1-290
Other Names BAIAP2;Brain-specific angiogenesis inhibitor 1-associated protein 2; Brain-specific angiogenesis inhibitor 1-associated protein 2; Fas ligand-associated factor 3; Brain-specific angiogenesis inhibitor 1-associated protein 2; Insulin receptor substrate p53/p58; Brain-specific angiogenesis inhibitor 1-associated protein 2; Insulin receptor substrate protein of 53 kDa
Dilution WB~~1:1000
Target/Specificity Purified His-tagged BAIAP2 protein was used to produced this monoclonal antibody.
Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsBAIAP2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BAIAP2
Function Adapter protein that links membrane-bound small G- proteins to cytoplasmic effector proteins. Necessary for CDC42- mediated reorganization of the actin cytoskeleton and for RAC1- mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions.
Cellular Location Cytoplasm. Membrane; Peripheral membrane protein. Cell projection, filopodium. Cell projection, ruffle Cytoplasm, cytoskeleton. Note=Detected throughout the cytoplasm in the absence of specific binding partners. Detected in filopodia and close to membrane ruffles. Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites
Tissue Location Isoform 1 and isoform 4 are expressed almost exclusively in brain. Isoform 4 is barely detectable in placenta, prostate and testis. A short isoform is ubiquitous, with the highest expression in liver, prostate, testis and placenta
Research Areas

BACKGROUND

Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection.

REFERENCES

Oda K., et al. Cytogenet. Cell Genet. 84:75-82(1999).
Okamura-Oho Y., et al. Hum. Mol. Genet. 8:947-957(1999).
Miyahara A., et al. J. Hum. Genet. 48:410-414(2003).
Suzuki Y., et al. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Hachiya T., et al. Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases.

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