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GSTP1 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
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  • 1 - GSTP1 Antibody (Center) AW5183
    Western blot analysis of lysates from K562,Y79,PC-3 cell line (from left to right), using GSTP1 Antibody (Center)(Cat. #AW5183). AW5183 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody.
  • 1 - GSTP1 Antibody (Center) AW5183
    Western blot analysis of lysates from rat lung tissue,Y79 cell line,rat testis tissue,PC-3 cell line (from left to right), using GSTP1 Antibody (Center)(Cat. #AW5183). AW5183 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody.Lysates at 20ug per lane.
  • 1 - GSTP1 Antibody (Center) AW5183
    Western blot analysis of lysates from mouse lung tissue lysate,Y79,K562,PC-3 cell line (from left to right), using GSTP1 Antibody (Center)(Cat. #AW5183). AW5183 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody.Lysates at 20ug per lane.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
IHC
Primary Accession P09211
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Clone Names RB20807
Calculated MW H=23;Rat=23 KDa
Additional info
Gene ID 2950
Other Names GSTP1; FAEES3; GST3; Glutathione S-transferase P; GST class-pi; GSTP1-1
Target/Specificity This GSTP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 97-126 amino acids from the Central region of human GSTP1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGSTP1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GSTP1
Synonyms FAEES3, GST3
Function Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.
Cellular Location Cytoplasm. Mitochondrion. Nucleus. Note=The 83 N-terminal amino acids function as un uncleaved transit peptide, and arginine residues within it are crucial for mitochondrial localization
Research Areas

BACKGROUND

Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases.

REFERENCES

Cho,H.J., et.al., Cancer Genet. Cytogenet. 198 (1), 40-46 (2010)
Kanai,M., et.al., Cancer Epidemiol 34 (2), 189-193 (2010)
Davila,S., et.al., Genes Immun. 11 (3), 232-238 (2010)

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