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OASL Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
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  • 1 - OASL Antibody (C-term) AW5164
    Western blot analysis of lysates from U-87 MG,PC-3,HT-29 cell line (from left to right), using OASL Antibody (T499)(Cat. #AW5164). AW5164 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody.Lysates at 20ug per lane.
  • 14 - OASL Antibody (C-term) AW5164
    Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
IHC-P, WB
Primary Accession Q15646
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW H=59,44 KDa
Isotype Rabbit Ig
Antigen Source HUMAN
Additional Information
Gene ID 8638
Antigen Region 484-514
Other Names OASL; TRIP14; 2'-5'-oligoadenylate synthase-like protein; 2'-5'-OAS-related protein; 59 kDa 2'-5'-oligoadenylate synthase-like protein; Thyroid receptor-interacting protein 14; p59 OASL
Dilution WB~~1:1000
IHC-P~~1:50~100
Target/Specificity This OASL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 484-514 amino acids from the C-terminal region of human OASL.
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsOASL Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name OASL
Synonyms TRIP14
Function Does not have 2'-5'-OAS activity, but can bind double- stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L.
Cellular Location Isoform p56: Nucleus, nucleolus. Cytoplasm.
Tissue Location Expressed in most tissues, with the highest levels in primary blood Leukocytes and other hematopoietic system tissues, colon, stomach and to some extent in testis
Research Areas

BACKGROUND

2-prime,5-prime oligoadenylates (2-5As) bind to and activate RNase L, leading to degradation of RNA and inhibition of protein synthesis. 2-5As are produced by 2-5A synthetases (OASs), a highly-conserved family of interferon-induced enzymes. The predicted 514-amino acid human p59OASL (2-5A synthetases-like) protein shares a highly conserved N-terminal domain with other OASs. The C-terminal portion of p59OASL contains 2 ubiquitin-like domains. p59OASL is expressed in most tissues, with the highest levels in hematopoietic tissues, colon, and stomach.

REFERENCES

Hovnanian, A., et al., Genomics 56(3):362-363 (1999).
Rebouillat, D., et al., Eur. J. Biochem. 257(2):319-330 (1998).
Hartmann, R., et al., Nucleic Acids Res. 26(18):4121-4128 (1998).
Lee, J.W., et al., Mol. Endocrinol. 9(2):243-254 (1995).
Mackay, V., et al., J. Biol. Chem. 251(12):3716-3719 (1976).

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