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AKR1B1 Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
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  • 1 - AKR1B1 Antibody (C-term) AW5144
    Western blot analysis of lysates from human placeta tissue and A375 cell line (from left to right), using AKR1B1 Antibody (C-term)(Cat. #AW5144). AW5144 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody.Lysates at 20ug per lane.
  • 14 - AKR1B1 Antibody (C-term) AW5144
    Formalin-fixed and paraffin-embedded human colon carcinoma tissue reacted with AKR1B1 antibody (C-term) (Cat.#AW5144), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • 3 - AKR1B1 Antibody (C-term) AW5144
    Confocal immunofluorescent analysis of AKR1B1 Antibody (C-term)(Cat#AW5144) with 293 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green).DAPI was used to stain the cell nuclear (blue).
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
IF, IHC-P, WB
Primary Accession P15121
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW H=36 KDa
Isotype Rabbit Ig
Antigen Source HUMAN
Additional Information
Gene ID 231
Antigen Region 290-316
Other Names AKR1B1; ALDR1; Aldose reductase; Aldehyde reductase; Aldo-keto reductase family 1 member B1
Dilution WB~~1:1000
IHC-P~~1:10~50
IF~~1:10~50
Target/Specificity This AKR1B1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 290-316 amino acids from the C-terminal region of human AKR1B1.
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsAKR1B1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name AKR1B1
Synonyms ALDR1
Function Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
Cellular Location Cytoplasm.
Tissue Location Highly expressed in embryonic epithelial cells (EUE) in response to osmotic stress.
Research Areas

BACKGROUND

AKR1B1 is a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This protein catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol.

REFERENCES

Steuber,H.,J. Mol. Biol. 379 (5), 991-1016 (2008)
Gleissner,C.A.,Arterioscler. Thromb. Vasc. Biol. 28 (6), 1137-1143 (2008)
Grundmann,U.,DNA Cell Biol. 9 (3), 149-157 (1990)

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