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SEMA7A Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
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  • 1 - SEMA7A Antibody (N-term) AW5121
    Western blot analysis of lysates from human placenta,mouse spleen tissue lysate (from left to right), using SEMA7A Antibody (N-term)(Cat. #AW5121). AW5121 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession O75326
Other Accession Q9QUR8
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW H=75;M=75 KDa
Isotype Rabbit Ig
Antigen Source Human
Additional Information
Gene ID 8482
Antigen Region 178-202
Other Names SEMA7A;CD108; SEMAL; Semaphorin-7A; Semaphorin-7A; CDw108; Semaphorin-7A; JMH blood group antigen; Semaphorin-7A; John-Milton-Hargen human blood group Ag; Semaphorin-7A; Semaphorin-K1; Semaphorin-7A; Semaphorin-L; Semaphorin-7A; CD_antigen=CD108; Flags: Precursor
Dilution WB~~1:1000
Target/Specificity This SEMA7A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 178-202 amino acids from the N-terminal region of human SEMA7A.
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSEMA7A Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SEMA7A
Synonyms CD108, SEMAL
Function Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes.
Cellular Location Cell membrane; Lipid- anchor, GPI-anchor; Extracellular side Note=Detected in a punctate pattern on the cell membrane of basal and supra-basal skin keratinocytes
Tissue Location Detected in skin keratinocytes and on endothelial cells from skin blood vessels (at protein level) Expressed in fibroblasts, keratinocytes, melanocytes, placenta, testis, ovary, spleen, brain, spinal chord, lung, heart, adrenal gland, lymph nodes, thymus, intestine and kidney
Research Areas

BACKGROUND

Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes.

REFERENCES

Lange C., et al. Genomics 51:340-350(1998).
Yamada A., et al. J. Immunol. 162:4094-4100(1999).
Xu X., et al. J. Biol. Chem. 273:22428-22434(1998).
Seltsam A., et al. Transfusion 47:133-146(2007).
Angelisova P., et al. Immunobiology 200:234-245(1999).

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