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CRTAP Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
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  • 1 - CRTAP Antibody (N-term) AW5097
    Western blot analysis of lysates from HT1080,ZR-75-1 cell line (from left to right), using CRTAP Antibody (N-term)(Cat. #AW5097). AW5097 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody.
  • 3 - CRTAP Antibody (N-term) AW5097
    Fluorescent image of Hela cells stained with CRTAP Antibody (N-term)(Cat#AW5097). AW5097 was diluted at 1:25 dilution. An Alexa Fluor 488-conjugated goat anti-rabbit lgG at 1:400 dilution was used as the secondary antibody (green). Cytoplasmic actin was counterstained with Alexa Fluor® 555 conjugated with Phalloidin (red).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
IF
Primary Accession O75718
Other Accession NP_006362.1
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Clone Names RB36912
Calculated MW H=47;M=46 KDa
Additional info
Gene ID 10491
Other Names CRTAP; CASP; Cartilage-associated protein
Target/Specificity This CRTAP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 31-59 amino acids from the N-terminal region of human CRTAP.
Dilution WB~~1:1000
IF~~1:25
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCRTAP Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CRTAP
Synonyms CASP
Function Necessary for efficient 3-hydroxylation of fibrillar collagen prolyl residues.
Cellular Location Secreted, extracellular space, extracellular matrix
Tissue Location Found in articular chondrocytes. Expressed in a variety of tissues
Research Areas

BACKGROUND

The protein encoded by this gene is similar to the chicken and mouse CRTAP genes. The encoded protein is a scaffolding protein that may influence the activity of at least one member of the cytohesin/ARNO family in response to specific cellular stimuli. Defects in this gene are associated with osteogenesis imperfecta, a connective tissue disorder characterized by bone fragility and low bone mass.

REFERENCES

Morello, R., et al. Curr Osteoporos Rep 8(2):77-83(2010)
Li, G.H., et al. Osteoporos Int 21(6):1009-1020(2010)
Fratzl-Zelman, N., et al. Bone 46(3):820-826(2010)
Chang, W., et al. Hum. Mol. Genet. 19(2):223-234(2010)
Marini, J.C., et al. Cell Tissue Res. 339(1):59-70(2010)

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