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HBB Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
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  • 1 - HBB Antibody (C-term) AW5085
    Western blot analysis of lysates from human liver tissue,K562 cell line (from left to right), using HBB Antibody (C-term)(Cat. #AW5085). AW5085 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody.Lysates at 20ug per lane.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession P68871
Other Accession P04246, P02101, P02128, P06643, P06642, P02042, P02057, P02112, P02081, P11517, P02089, P02091, P02088, NP_000509.1
Reactivity Human
Predicted Mouse, Rat, Rabbit, Bovine, Chicken
Host Rabbit
Clonality Polyclonal
Calculated MW H=16 KDa
Isotype Rabbit Ig
Antigen Source HUMAN
Additional Information
Gene ID 3043
Antigen Region 80-107
Other Names HBB; Hemoglobin subunit beta; Beta-globin; Hemoglobin beta chain; LVV-hemorphin-7
Dilution WB~~1:1000
Target/Specificity This HBB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 80-107 amino acids from the C-terminal region of human HBB.
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHBB Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HBB
Function Involved in oxygen transport from the lung to the various peripheral tissues. Spinorphin: functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulator of pain and inflammation.
Tissue Location Red blood cells..
Research Areas

BACKGROUND

The alpha (HBA) and beta (HBB) loci determine the structure of the 2 types of polypeptide chains in adult hemoglobin, Hb A. The normal adult hemoglobin tetramer consists of two alpha chains and two beta chains. Mutant beta globin causes sickle cell anemia. Absence of beta chain causes beta-zero-thalassemia. Reduced amounts of detectable beta globin causes beta-plus-thalassemia. The order of the genes in the beta-globin cluster is 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'.

REFERENCES

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Zhou, D., et al. Nat. Genet. 42(9):742-744(2010)
Onakoya, P.A., et al. Ear Nose Throat J 89(7):306-310(2010)
Belisario, A.R., et al. Acta Haematol. 124(3):162-170(2010)
Prakobkaew, N., et al. Acta Haematol. 124(2):115-119(2010)

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