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AHSG Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
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  • 1 - AHSG Antibody (C-term) AW5083
    Western blot analysis of lysates from human plasma and liver tissue lysate (from left to right), using AHSG Antibody (C-term)(Cat. #AW5083). AW5083 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession P02765
Other Accession NP_001613.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW H=39 KDa
Isotype Rabbit Ig
Antigen Source HUMAN
Additional Information
Gene ID 197
Antigen Region 247-276
Other Names AHSG; FETUA; Alpha-2-HS-glycoprotein; Alpha-2-Z-globulin; Ba-alpha-2-glycoprotein; Fetuin-A; Alpha-2-HS-glycoprotein chain A; Alpha-2-HS-glycoprotein chain B
Dilution WB~~1:1000
Target/Specificity This AHSG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 247-276 amino acids from the C-terminal region of human AHSG.
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsAHSG Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name AHSG
Synonyms FETUA
Function Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions.
Cellular Location Secreted.
Tissue Location Synthesized in liver and selectively concentrated in bone matrix. Secreted in plasma. It is also found in dentin in much higher quantities than other plasma proteins
Research Areas
Facilitatory effects of fetuin-A on atherosclerosis.
Author : Naito C1, Hashimoto M1, Watanabe K1, Shirai R1, Takahashi Y1, Kojima M1, Watanabe R1, Sato K1, Iso Y2, Matsuyama TA3, Suzuki H2, Ishib
Atherosclerosis. 2016 Jan 22;246:344-351. doi: 10.1016/j.atherosclerosis.2016.01.037. [Epub ahead of print]
26828753

BACKGROUND

Alpha2-HS glycoprotein (AHSG), a glycoprotein present in the serum, is synthesized by hepatocytes. The AHSG molecule consists of two polypeptide chains, which are both cleaved from a proprotein encoded from a single mRNA. It is involved in several functions, such as endocytosis, brain development and the formation of bone tissue. The protein is commonly present in the cortical plate of the immature cerebral cortex and bone marrow hemopoietic matrix, and it has therefore been postulated that it participates in the development of the tissues. However, its exact significance is still obscure.

REFERENCES

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010) Verduijn, M., et al. Nephrol. Dial. Transplant. (2010) In press : Wang, Y., et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 27(3):310-315(2010) Voigt, M., et al. Histopathology 56(6):775-788(2010) Kusnierz-Cabala, B., et al. Clin. Lab. 56 (5-6), 191-195 (2010) :

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