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CBX8 Antibody (C-term)

Purified Mouse Monoclonal Antibody (Mab)

     
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  • 1 - CBX8 Antibody (C-term) AW5081
    Western blot analysis of lysates from A549,Hela cell line (from left to right), using CBX8 Antibody (C-term)(Cat. #AW5081). AW5081 was diluted at 1:1000 at each lane. A goat anti-mouse IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody.
  • 4 - CBX8 Antibody (C-term) AW5081
    Flow cytometric analysis of A549 cells using CBX8 Antibody (C-term)(green, Cat#AW5081) compared to an isotype control of mouse IgG1(blue). AP20600c was diluted at 1:25 dilution. An Alexa Fluor® 488 goat anti-mouse lgG at 1:400 dilution was used as the secondary antibody.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
FC, WB
Primary Accession Q9HC52
Reactivity Human
Host Mouse
Clonality monoclonal
Calculated MW H=43 KDa
Isotype IgG1
Antigen Source HUMAN
Additional Information
Gene ID 57332
Other Names Chromobox protein homolog 8, Polycomb 3 homolog, Pc3, hPc3, Rectachrome 1, CBX8, PC3, RC1
Dilution WB~~1:1000
FC~~1:25
Target/Specificity This CBX8 antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between amino acids from the C-terminal region of human CBX8.
Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCBX8 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CBX8
Synonyms PC3, RC1
Function Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
Cellular Location Nucleus.

BACKGROUND

Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.

REFERENCES

Bardos J.I.,et al.J. Biol. Chem. 275:28785-28792(2000).
Michael M.Z.,et al.Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Garcia-Cuellar M.P.,et al.Oncogene 20:411-419(2001).
Levine S.S.,et al.Mol. Cell. Biol. 22:6070-6078(2002).

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